Student Publications

Blessing, C., and Ladurner, A.G. (2020). Tickling PARPs into serine action. Nat Struct Mol Biol, [Epub ahead of print].

Dolensek, N., Gehrlach, D.A., Klein, A.S., and Gogolla, N. (2020). Facial expressions of emotion states and their neuronal correlates in mice. Science 368, 89-94.

Kober-Hasslacher, M., Oh-Strauß, H., Kumar, D., Soberón, V., Diehl, C., Lech, M., Engleitner, T., Katab, E., Fernandez Saiz, V., Piontek, G., Li, H., Menze, B., Ziegenhain, C., Enard, W., Rad, R., Böttcher, J.P., Anders, H.J., Rudelius, M., and Schmidt-Supprian, M. (2020). c-Rel gain in B cells drives germinal center reactions and autoantibody production. J Clin Invest.

Yim, A., Koti, P., Bonnard, A., Marchiano, F., Durrbaum, M., Garcia-Perez, C., Villaveces, J., Gamal, S., Cardone, G., Perocchi, F., Storchova, Z., and Habermann, B.H. (2020). mitoXplorer, a visual data mining platform to systematically analyze and visualize mitochondrial expression dynamics and mutations. Nucleic Acids Res 48, 605-632.

Bantele, S.C.S., and Pfander, B. (2020). Quantitative mechanisms of DNA damage sensing and signaling. Current genetics 66, 59-62.

Lee, C.W., Wilfling, F., Ronchi, P., Allegretti, M., Mosalaganti, S., Jentsch, S., Beck, M., and Pfander, B. (2020). Selective autophagy degrades nuclear pore complexes. Nat Cell Biol 22, 159-166.

Schlepckow, K., Monroe, K.M., Kleinberger, G., Cantuti-Castelvetri, L., Parhizkar, S., Xia, D., Willem, M., Werner, G., Pettkus, N., Brunner, B., Sülzen, A., Nuscher, B., Hampel, H., Xiang, X., Feederle, R., Tahirovic, S., Park, J.I., Prorok, R., Mahon, C., Liang, C.C., Shi, J., Kim, D.J., Sabelström, H., Huang, F., Di Paolo, G., Simons, M., Lewcock, J.W., and Haass, C. (2020). Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med, e11227.

Del Toro, D., Carrasquero-Ordaz, M.A., Chu, A., Ruff, T., Shahin, M., Jackson, V.A., Chavent, M., Berbeira-Santana, M., Seyit-Bremer, G., Brignani, S., Kaufmann, R., Lowe, E., Klein, R., and Seiradake, E. (2020). Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons. Cell 180, 323-339 e319.

Stief, S.M., Hanneforth, A.L., Weser, S., Mattes, R., Carlet, M., Liu, W.H., Bartoschek, M.D., Dominguez Moreno, H., Oettle, M., Kempf, J., Vick, B., Ksienzyk, B., Tizazu, B., Rothenberg-Thurley, M., Quentmeier, H., Hiddemann, W., Vosberg, S., Greif, P.A., Metzeler, K.H., Schotta, G., Bultmann, S., Jeremias, I., Leonhardt, H., and Spiekermann, K. (2020). Loss of KDM6A confers drug resistance in acute myeloid leukemia. Leukemia 34, 50-62.

Deng, W., Bates, J.A., Wei, H., Bartoschek, M.D., Conradt, B., and Leonhardt, H. (2020). Tunable light and drug induced depletion of target proteins. Nat Commun 11, 304.

Albert, S., Wietrzynski, W., Lee, C.W., Schaffer, M., Beck, F., Schuller, J.M., Salome, P.A., Plitzko, J.M., Baumeister, W., and Engel, B.D. (2020). Direct visualization of degradation microcompartments at the ER membrane. Proc Natl Acad Sci U S A 117, 1069-1080.

Auer, A., Strauss, M.T., Strauss, S., and Jungmann, R. (2020). nanoTRON: a Picasso module for MLP-based classification of super-resolution data. Bioinformatics.

Bartnik, K., Barth, A., Pilo-Pais, M., Crevenna, A.H., Liedl, T., and Lamb, D.C. (2020). A DNA Origami Platform for Single-Pair Forster Resonance Energy Transfer Investigation of DNA-DNA Interactions and Ligation. J Am Chem Soc 142, 815-825.

Qiao, S., Langlois, C.R., Chrustowicz, J., Sherpa, D., Karayel, O., Hansen, F.M., Beier, V., von Gronau, S., Bollschweiler, D., Schafer, T., Alpi, A.F., Mann, M., Prabu, J.R., and Schulman, B.A. (2020). Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. Mol Cell 77, 150-163 e159.

Hergenhan, S., Holtkamp, S., and Scheiermann, C. (2020). Molecular interactions between components of the circadian clock and the immune system. J Mol Biol.

Nishiyama, A., Mulholland, C.B., Bultmann, S., Kori, S., Endo, A., Saeki, Y., Qin, W., Trummer, C., Chiba, Y., Yokoyama, H., Kumamoto, S., Kawakami, T., Hojo, H., Nagae, G., Aburatani, H., Tanaka, K., Arita, K., Leonhardt, H., and Nakanishi, M. (2020). Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nat Commun 11, 1222.

Chen, J., Brunner, A.D., Cogan, J.Z., Nuñez, J.K., Fields, A.P., Adamson, B., Itzhak, D.N., Li, J.Y., Mann, M., Leonetti, M.D., and Weissman, J.S. (2020). Pervasive functional translation of noncanonical human open reading frames. Science 367, 1140-1146.

Baek, K., and Schulman, B.A. (2020). Molecular glue concept solidifies. Nat Chem Biol 16, 2-3.

Libicher, K., Hornberger, R., Heymann, M., and Mutschler, H. (2020). In vitro self-replication and multicistronic expression of large synthetic genomes. Nat Commun 11, 904.

Rehn, A., Lawatscheck, J., Jokisch, M.L., Mader, S.L., Luo, Q., Tippel, F., Blank, B., Richter, K., Lang, K., Kaila, V.R.I., and Buchner, J. (2020). A methylated lysine is a switch point for conformational communication in the chaperone Hsp90. Nat Commun 11, 1219.

Swietlik, J.J., Sinha, A., and Meissner, F. (2020). Dissecting intercellular signaling with mass spectrometry-based proteomics. Curr Opin Cell Biol 63, 20-30.

Coscia, F., Doll, S., Bech, J.M., Schweizer, L., Mund, A., Lengyel, E., Lindebjerg, J., Madsen, G.I., Moreira, J.M.A., and Mann, M. (2020). A streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis. J Pathol.

Monkemeyer, L., Klaips, C.L., Balchin, D., Korner, R., Hartl, F.U., and Bracher, A. (2019). Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2. Mol Cell 74, 88-100 e109.

De Oliveira, T., Ramakrishnan, M., Diamanti, M.A., Ziegler, P.K., Brombacher, F., and Greten, F.R. (2019). Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis. Oncogene 38, 1787-1801.

van Well, E.M., Bader, V., Patra, M., Sanchez-Vicente, A., Meschede, J., Furthmann, N., Schnack, C., Blusch, A., Longworth, J., Petrasch-Parwez, E., Mori, K., Arzberger, T., Trumbach, D., Angersbach, L., Showkat, C., Sehr, D.A., Berlemann, L.A., Goldmann, P., Clement, A.M., Behl, C., Woerner, A.C., Saft, C., Wurst, W., Haass, C., Ellrichmann, G., Gold, R., Dittmar, G., Hipp, M.S., Hartl, F.U., Tatzelt, J., and Winklhofer, K.F. (2019). A protein quality control pathway regulated by linear ubiquitination. EMBO J 38.

Matscheko, N., Mayrhofer, P., Rao, Y., Beier, V., and Wollert, T. (2019). Atg11 tethers Atg9 vesicles to initiate selective autophagy. PLoS Biol 17, e3000377.

Lee, Y., Yoon, E., Cho, S., Schmahling, S., Muller, J., and Song, J.J. (2019). Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop. Structure 27, 846-852 e843.

Bajc Cesnik, A., Darovic, S., Prpar Mihevc, S., Stalekar, M., Malnar, M., Motaln, H., Lee, Y.B., Mazej, J., Pohleven, J., Grosch, M., Modic, M., Fonovic, M., Turk, B., Drukker, M., Shaw, C.E., and Rogelj, B. (2019). Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. J Cell Sci 132.

Lepko, T., Pusch, M., Muller, T., Schulte, D., Ehses, J., Kiebler, M., Hasler, J., Huttner, H.B., Vandenbroucke, R.E., Vandendriessche, C., Modic, M., Martin-Villalba, A., Zhao, S., E, L.L.-B., Schneider, A., Fischer, A., Breunig, C.T., Stricker, S.H., Gotz, M., and Ninkovic, J. (2019). Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. EMBO J 38, e100481.

Matheus, F., Rusha, E., Rehimi, R., Molitor, L., Pertek, A., Modic, M., Feederle, R., Flatley, A., Kremmer, E., Geerlof, A., Rishko, V., Rada-Iglesias, A., and Drukker, M. (2019). Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development. Stem cell reports 12, 861-868.

La Chioma, A., Bonhoeffer, T., and Hubener, M. (2019). Area-Specific Mapping of Binocular Disparity across Mouse Visual Cortex. Curr Biol 29, 2954-2960 e2955.

Mariappan, A., Soni, K., Schorpp, K., Zhao, F., Minakar, A., Zheng, X., Mandad, S., Macheleidt, I., Ramani, A., Kubelka, T., Dawidowski, M., Golfmann, K., Wason, A., Yang, C., Simons, J., Schmalz, H.G., Hyman, A.A., Aneja, R., Ullrich, R., Urlaub, H., Odenthal, M., Buttner, R., Li, H., Sattler, M., Hadian, K., and Gopalakrishnan, J. (2019). Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. EMBO J 38.

Modic, M., Grosch, M., Rot, G., Schirge, S., Lepko, T., Yamazaki, T., Lee, F.C.Y., Rusha, E., Shaposhnikov, D., Palo, M., Merl-Pham, J., Cacchiarelli, D., Rogelj, B., Hauck, S.M., von Mering, C., Meissner, A., Lickert, H., Hirose, T., Ule, J., and Drukker, M. (2019). Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Mol Cell 74, 951-965 e913.

Burgold, J., Schulz-Trieglaff, E.K., Voelkl, K., Gutierrez-Angel, S., Bader, J.M., Hosp, F., Mann, M., Arzberger, T., Klein, R., Liebscher, S., and Dudanova, I. (2019). Cortical circuit alterations precede motor impairments in Huntington's disease mice. Sci Rep 9, 6634.

Schopf, F.H., Huber, E.M., Dodt, C., Lopez, A., Biebl, M.M., Rutz, D.A., Muhlhofer, M., Richter, G., Madl, T., Sattler, M., Groll, M., and Buchner, J. (2019). The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2. Mol Cell 74, 73-87 e78.

Winklmeier, S., Schluter, M., Spadaro, M., Thaler, F.S., Vural, A., Gerhards, R., Macrini, C., Mader, S., Kurne, A., Inan, B., Karabudak, R., Ozbay, F.G., Esendagli, G., Hohlfeld, R., Kumpfel, T., and Meinl, E. (2019). Identification of circulating MOG-specific B cells in patients with MOG antibodies. Neurology(R) neuroimmunology & neuroinflammation 6, 625.

Wang, H., Yan, X., Aigner, H., Bracher, A., Nguyen, N.D., Hee, W.Y., Long, B.M., Price, G.D., Hartl, F.U., and Hayer-Hartl, M. (2019). Rubisco condensate formation by CcmM in beta-carboxysome biogenesis. Nature 566, 131-135.

Weckmann, K., Deery, M.J., Howard, J.A., Feret, R., Asara, J.M., Dethloff, F., Filiou, M.D., Labermaier, C., Maccarrone, G., Lilley, K.S., Mueller, M., and Turck, C.W. (2019). Ketamine's Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice. Molecular neuropsychiatry 5, 42-51.

Cosolo, A., Jaiswal, J., Csordas, G., Grass, I., Uhlirova, M., and Classen, A.K. (2019). JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress. Elife 8.

Bantele, S.C.S., and Pfander, B. (2019). Nucleosome Remodeling by Fun30(SMARCAD1) in the DNA Damage Response. Frontiers in molecular biosciences 6, 78.

Bantele, S.C.S., Lisby, M., and Pfander, B. (2019). Quantitative sensing and signalling of single-stranded DNA during the DNA damage response. Nat Commun 10, 944.

Balaji, R., Weichselberger, V., and Classen, A.K. (2019). Response of Drosophila epithelial cell and tissue shape to external forces in vivo. Development 146.

Stein, J., Stehr, F., Schueler, P., Blumhardt, P., Schueder, F., Mucksch, J., Jungmann, R., and Schwille, P. (2019). Toward Absolute Molecular Numbers in DNA-PAINT. Nano Lett 19, 8182-8190.

Hopfler, M., Kern, M.J., Straub, T., Prytuliak, R., Habermann, B.H., Pfander, B., and Jentsch, S. (2019). Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance. EMBO J 38.

Harpprecht, L., Baldi, S., Schauer, T., Schmidt, A., Bange, T., Robles, M.S., Kremmer, E., Imhof, A., and Becker, P.B. (2019). A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling. Nucleic Acids Res 47, 7444-7459.

Gorgulu, K., Diakopoulos, K.N., Ai, J., Schoeps, B., Kabacaoglu, D., Karpathaki, A.F., Ciecielski, K.J., Kaya-Aksoy, E., Ruess, D.A., Berninger, A., Kowalska, M., Stevanovic, M., Wormann, S.M., Wartmann, T., Zhao, Y., Halangk, W., Voronina, S., Tepikin, A., Schlitter, A.M., Steiger, K., Artati, A., Adamski, J., Aichler, M., Walch, A., Jastroch, M., Hartleben, G., Mantzoros, C.S., Weichert, W., Schmid, R.M., Herzig, S., Kruger, A., Sainz, B., Jr., Lesina, M., and Algul, H. (2019). Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice. Gastroenterology 156, 203-217.e220.

Glock, P., Ramm, B., Heermann, T., Kretschmer, S., Schweizer, J., Mucksch, J., Alagoz, G., and Schwille, P. (2019). Stationary Patterns in a Two-Protein Reaction-Diffusion System. ACS synthetic biology 8, 148-157.

Betaneli, V., Mucksch, J., and Schwille, P. (2019). Fluorescence Correlation Spectroscopy to Examine Protein-Lipid Interactions in Membranes. Methods Mol Biol 2003, 415-447.

Stih, V., Petrucco, L., Kist, A.M., and Portugues, R. (2019). Stytra: An open-source, integrated system for stimulation, tracking and closed-loop behavioral experiments. PLoS Comput Biol 15, e1006699.

Lemke, S.B., Weidemann, T., Cost, A.L., Grashoff, C., and Schnorrer, F. (2019). A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo. PLoS Biol 17, e3000057.

Knogler, L.D., Kist, A.M., and Portugues, R. (2019). Motor context dominates output from Purkinje cell functional regions during reflexive visuomotor behaviours. Elife 8.

Kist, A.M., and Portugues, R. (2019). Optomotor Swimming in Larval Zebrafish Is Driven by Global Whole-Field Visual Motion and Local Light-Dark Transitions. Cell Rep 29, 659-670.e653.

Gehrlach, D.A., Dolensek, N., Klein, A.S., Roy Chowdhury, R., Matthys, A., Junghanel, M., Gaitanos, T.N., Podgornik, A., Black, T.D., Reddy Vaka, N., Conzelmann, K.K., and Gogolla, N. (2019). Aversive state processing in the posterior insular cortex. Nat Neurosci 22, 1424-1437.

Cost, A.L., Khalaji, S., and Grashoff, C. (2019). Genetically Encoded FRET-Based Tension Sensors. Current protocols in cell biology, e85.

Lingaraju, M., Johnsen, D., Schlundt, A., Langer, L.M., Basquin, J., Sattler, M., Heick Jensen, T., Falk, S., and Conti, E. (2019). The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nat Commun 10, 3393.

Gat, Y., Schuller, J.M., Lingaraju, M., Weyher, E., Bonneau, F., Strauss, M., Murray, P.J., and Conti, E. (2019). InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex. Nat Struct Mol Biol 26, 1089-1093.

Albert, S., Wietrzynski, W., Lee, C.W., Schaffer, M., Beck, F., Schuller, J.M., Salome, P.A., Plitzko, J.M., Baumeister, W., and Engel, B.D. (2020). Direct visualization of degradation microcompartments at the ER membrane. Proc Natl Acad Sci U S A 117, 1069-1080.

Zhou, Q., Mareljic, N., Michaelsen, M., Parhizkar, S., Heindl, S., Nuscher, B., Farny, D., Czuppa, M., Schludi, C., Graf, A., Krebs, S., Blum, H., Feederle, R., Roth, S., Haass, C., Arzberger, T., Liesz, A., and Edbauer, D. (2019). Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. EMBO Mol Med, e10919.

Zannas, A.S., Jia, M., Hafner, K., Baumert, J., Wiechmann, T., Pape, J.C., Arloth, J., Kodel, M., Martinelli, S., Roitman, M., Roh, S., Haehle, A., Emeny, R.T., Iurato, S., Carrillo-Roa, T., Lahti, J., Raikkonen, K., Eriksson, J.G., Drake, A.J., Waldenberger, M., Wahl, S., Kunze, S., Lucae, S., Bradley, B., Gieger, C., Hausch, F., Smith, A.K., Ressler, K.J., Muller-Myhsok, B., Ladwig, K.H., Rein, T., Gassen, N.C., and Binder, E.B. (2019). Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappaB-driven inflammation and cardiovascular risk. Proc Natl Acad Sci U S A 116, 11370-11379.

Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., Krasemann, S., Lichtenthaler, S.F., Muller, S.A., Colombo, A., Monasor, L.S., Tahirovic, S., Herms, J., Willem, M., Pettkus, N., Butovsky, O., Bartenstein, P., Edbauer, D., Rominger, A., Erturk, A., Grathwohl, S.A., Neher, J.J., Holtzman, D.M., Meyer-Luehmann, M., and Haass, C. (2019). Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nat Neurosci 22, 191-204.

Papadopoulou, A.A., Muller, S.A., Mentrup, T., Shmueli, M.D., Niemeyer, J., Haug-Kroper, M., von Blume, J., Mayerhofer, A., Feederle, R., Schroder, B., Lichtenthaler, S.F., and Fluhrer, R. (2019). Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO Rep 20.

Niemeyer, J., Mentrup, T., Heidasch, R., Muller, S.A., Biswas, U., Meyer, R., Papadopoulou, A.A., Dederer, V., Haug-Kroper, M., Adamski, V., Lullmann-Rauch, R., Bergmann, M., Mayerhofer, A., Saftig, P., Wennemuth, G., Jessberger, R., Fluhrer, R., Lichtenthaler, S.F., Lemberg, M.K., and Schroder, B. (2019). The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Rep 20.

Gotzl, J.K., Brendel, M., Werner, G., Parhizkar, S., Sebastian Monasor, L., Kleinberger, G., Colombo, A.V., Deussing, M., Wagner, M., Winkelmann, J., Diehl-Schmid, J., Levin, J., Fellerer, K., Reifschneider, A., Bultmann, S., Bartenstein, P., Rominger, A., Tahirovic, S., Smith, S.T., Madore, C., Butovsky, O., Capell, A., and Haass, C. (2019). Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med 11.

Gassen, N.C., Niemeyer, D., Muth, D., Corman, V.M., Martinelli, S., Gassen, A., Hafner, K., Papies, J., Mosbauer, K., Zellner, A., Zannas, A.S., Herrmann, A., Holsboer, F., Brack-Werner, R., Boshart, M., Muller-Myhsok, B., Drosten, C., Muller, M.A., and Rein, T. (2019). SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nat Commun 10, 5770.

Kramer, A., Wu, Y., Baier, H., and Kubo, F. (2019). Neuronal Architecture of a Visual Center that Processes Optic Flow. Neuron 103, 118-132 e117.

Fan, Y., Bazai, S.K., Daian, F., Arechederra, M., Richelme, S., Temiz, N.A., Yim, A., Habermann, B.H., Dono, R., Largaespada, D.A., and Maina, F. (2019). Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis. J Hepatol 70, 470-482.

Wade, O.K., Woehrstein, J.B., Nickels, P.C., Strauss, S., Stehr, F., Stein, J., Schueder, F., Strauss, M.T., Ganji, M., Schnitzbauer, J., Grabmayr, H., Yin, P., Schwille, P., and Jungmann, R. (2019). 124-Color Super-resolution Imaging by Engineering DNA-PAINT Blinking Kinetics. Nano Lett 19, 2641-2646.

Schaffer, M., Pfeffer, S., Mahamid, J., Kleindiek, S., Laugks, T., Albert, S., Engel, B.D., Rummel, A., Smith, A.J., Baumeister, W., and Plitzko, J.M. (2019). A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native Caenorhabditis elegans tissue. Nat Methods 16, 757-762.

Rast, A., Schaffer, M., Albert, S., Wan, W., Pfeffer, S., Beck, F., Plitzko, J.M., Nickelsen, J., and Engel, B.D. (2019). Biogenic regions of cyanobacterial thylakoids form contact sites with the plasma membrane. Nature plants 5, 436-446.

Kabacaoglu, D., Ruess, D.A., Ai, J., and Algul, H. (2019). NF-kappaB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB. Cancers 11.

Jochheim, L.S., Odysseos, G., Hidalgo-Sastre, A., Zhong, S., Staufer, L.M., Kroiss, M., Kabacaoglu, D., Lange, S., Engleitner, T., Hartmann, D., Huser, N., Steiger, K., Schmid, R.M., Holzmann, B., and von Figura, G. (2019). The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice. Pancreatology 19, 541-547.

Glock, P., Brauns, F., Halatek, J., Frey, E., and Schwille, P. (2019). Design of biochemical pattern forming systems from minimal motifs. Elife 8.

Eto, H., Soga, N., Franquelim, H.G., Glock, P., Khmelinskaia, A., Kai, L., Heymann, M., Noji, H., and Schwille, P. (2019). Design of Sealable Custom-Shaped Cell Mimicries Based on Self-Assembled Monolayers on CYTOP Polymer. ACS applied materials & interfaces 11, 21372-21380.

Schueder, F., Stein, J., Stehr, F., Auer, A., Sperl, B., Strauss, M.T., Schwille, P., and Jungmann, R. (2019). An order of magnitude faster DNA-PAINT imaging by optimized sequence design and buffer conditions. Nat Methods 16, 1101-1104.

Kempter, S., Khmelinskaia, A., Strauss, M.T., Schwille, P., Jungmann, R., Liedl, T., and Bae, W. (2019). Single Particle Tracking and Super-Resolution Imaging of Membrane-Assisted Stop-and-Go Diffusion and Lattice Assembly of DNA Origami. ACS Nano 13, 996-1002.

Dedden, D., Schumacher, S., Kelley, C.F., Zacharias, M., Biertumpfel, C., Fassler, R., and Mizuno, N. (2019). The Architecture of Talin1 Reveals an Autoinhibition Mechanism. Cell 179, 120-131.e113.

Chiasson, D., Gimenez-Oya, V., Bircheneder, M., Bachmaier, S., Studtrucker, T., Ryan, J., Sollweck, K., Leonhardt, H., Boshart, M., Dietrich, P., and Parniske, M. (2019). A unified multi-kingdom Golden Gate cloning platform. Sci Rep 9, 10131.

Boger, C., Hafner, A.S., Schlichtharle, T., Strauss, M.T., Malkusch, S., Endesfelder, U., Jungmann, R., Schuman, E.M., and Heilemann, M. (2019). Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography. Neurophotonics 6, 035008.

Hsia, H.E., Tushaus, J., Brummer, T., Zheng, Y., Scilabra, S.D., and Lichtenthaler, S.F. (2019). Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system. Cell Mol Life Sci 76, 3055-3081.

Hubel, P., Urban, C., Bergant, V., Schneider, W.M., Knauer, B., Stukalov, A., Scaturro, P., Mann, A., Brunotte, L., Hoffmann, H.H., Schoggins, J.W., Schwemmle, M., Mann, M., Rice, C.M., and Pichlmair, A. (2019). A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol 20, 493-502.

Geyer, P.E., Voytik, E., Treit, P.V., Doll, S., Kleinhempel, A., Niu, L., Muller, J.B., Buchholtz, M.L., Bader, J.M., Teupser, D., Holdt, L.M., and Mann, M. (2019). Plasma Proteome Profiling to detect and avoid sample-related biases in biomarker studies. EMBO Mol Med, e10427.

Gebhardt, A., Bergant, V., Schnepf, D., Moser, M., Meiler, A., Togbe, D., Mackowiak, C., Reinert, L., Paludan, S.R., Ryffel, B., Stukalov, A., Staeheli, P., and Pichlmair, A. (2019). The alternative cap-binding complex is required for antiviral defense in vivo. PLoS Pathog 15, e1008155.

de Sousa-Pereira, P., Abrantes, J., Bauernfried, S., Pierini, V., Esteves, P.J., Keppler, O.T., Pizzato, M., Hornung, V., Fackler, O.T., and Baldauf, H.M. (2019). The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists. J Gen Virol 100, 278-288.

Lichtenthaler, S.F., and Guner, G. (2019). Pathology-linked protease caught in action. Science 363, 690-691.

Kuo, T.T., and Ladurner, A.G. (2019). Exploiting the Circadian Clock for Improved Cancer Therapy: Perspective From a Cell Biologist. Front Genet 10, 1210.

Kashammer, L., Saathoff, J.H., Lammens, K., Gut, F., Bartho, J., Alt, A., Kessler, B., and Hopfner, K.P. (2019). Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol Cell 76, 382-394 e386.

de Juan, A., Ince, L.M., Pick, R., Chen, C.S., Molica, F., Zuchtriegel, G., Wang, C., Zhang, D., Druzd, D., Hessenauer, M.E.T., Pelli, G., Kolbe, I., Oster, H., Prophete, C., Hergenhan, S.M., Albrecht, U., Ripperger, J., Montanez, E., Reichel, C.A., Soehnlein, O., Kwak, B.R., Frenette, P.S., and Scheiermann, C. (2019). Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins. Circulation.

van Emden, T.S., Forn, M., Forne, I., Sarkadi, Z., Capella, M., Martin Caballero, L., Fischer-Burkart, S., Bronner, C., Simonetta, M., Toczyski, D., Halic, M., Imhof, A., and Braun, S. (2019). Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability. EMBO Rep 20.

van Emden, T.S., and Braun, S. (2019). TASks for subtelomeres: when nucleosome loss and genome instability are favored. Current genetics 65, 1153-1160.

Wichmann, C., Meier, F., Virreira Winter, S., Brunner, A.D., Cox, J., and Mann, M. (2019). MaxQuant.Live Enables Global Targeting of More Than 25,000 Peptides. Mol Cell Proteomics 18, 982-994.

Huttenhain, R., Xu, J., Burton, L.A., Gordon, D.E., Hultquist, J.F., Johnson, J.R., Satkamp, L., Hiatt, J., Rhee, D.Y., Baek, K., Crosby, D.C., Frankel, A.D., Marson, A., Harper, J.W., Alpi, A.F., Schulman, B.A., Gross, J.D., and Krogan, N.J. (2019). ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host Microbe.

Deshmukh, A.S., Peijs, L., Beaudry, J.L., Jespersen, N.Z., Nielsen, C.H., Ma, T., Brunner, A.D., Larsen, T.J., Bayarri-Olmos, R., Prabhakar, B.S., Helgstrand, C., Severinsen, M.C.K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Prive, G.G., Pedersen, B.K., Gerhart-Hines, Z., Nielsen, S., Drucker, D.J., Mann, M., and Scheele, C. (2019). Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine. Cell Metab 30, 963-975.e967.

Fazel, M., Wester, M.J., Mazloom-Farsibaf, H., Meddens, M.B.M., Eklund, A.S., Schlichthaerle, T., Schueder, F., Jungmann, R., and Lidke, K.A. (2019). Bayesian Multiple Emitter Fitting using Reversible Jump Markov Chain Monte Carlo. Sci Rep 9, 13791.

Cramer, K., Bolender, A.L., Stockmar, I., Jungmann, R., Kasper, R., and Shin, J.Y. (2019). Visualization of Bacterial Protein Complexes Labeled with Fluorescent Proteins and Nanobody Binders for STED Microscopy. International journal of molecular sciences 20.

Mayer, S.V., Murnauer, A., von Wrisberg, M.K., Jokisch, M.L., and Lang, K. (2019). Photo-induced and Rapid Labeling of Tetrazine-Bearing Proteins via Cyclopropenone-Caged Bicyclononynes. Angew Chem Int Ed Engl 58, 15876-15882.

Yan, X., Shi, Q., Bracher, A., Milicic, G., Singh, A.K., Hartl, F.U., and Hayer-Hartl, M. (2018). GroEL Ring Separation and Exchange in the Chaperonin Reaction. Cell 172, 605-617 e611.

Balchin, D., Milicic, G., Strauss, M., Hayer-Hartl, M., and Hartl, F.U. (2018). Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC. Cell 174, 1507-1521 e1516.

Lehmer, C., Schludi, M.H., Ransom, L., Greiling, J., Junghanel, M., Exner, N., Riemenschneider, H., van der Zee, J., Van Broeckhoven, C., Weydt, P., Heneka, M.T., and Edbauer, D. (2018). A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS. EMBO Mol Med 10.

Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Perez-Berlanga, M., Frottin, F., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., and Fernandez-Busnadiego, R. (2018). In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell 172, 696-705 e612.

Rosam, M., Krader, D., Nickels, C., Hochmair, J., Back, K.C., Agam, G., Barth, A., Zeymer, C., Hendrix, J., Schneider, M., Antes, I., Reinstein, J., Lamb, D.C., and Buchner, J. (2018). Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate. Nat Struct Mol Biol 25, 90-100.

Strauss, M.T., Schueder, F., Haas, D., Nickels, P.C., and Jungmann, R. (2018). Quantifying absolute addressability in DNA origami with molecular resolution. Nat Commun 9, 1600.

Schmahling, S., Meiler, A., Lee, Y., Mohammed, A., Finkl, K., Tauscher, K., Israel, L., Wirth, M., Philippou-Massier, J., Blum, H., Habermann, B., Imhof, A., Song, J.J., and Muller, J. (2018). Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC. Development 145.

Vincenz-Donnelly, L., Holthusen, H., Korner, R., Hansen, E.C., Presto, J., Johansson, J., Sawarkar, R., Hartl, F.U., and Hipp, M.S. (2018). High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins. EMBO J 37, 337-350.

Spadaro, M., Winklmeier, S., Beltran, E., Macrini, C., Hoftberger, R., Schuh, E., Thaler, F.S., Gerdes, L.A., Laurent, S., Gerhards, R., Brandle, S., Dornmair, K., Breithaupt, C., Krumbholz, M., Moser, M., Kirshnamoorthy, G., Kamp, F., Jenne, D., Hohlfeld, R., Kumpfel, T., Lassmann, H., Kawakami, N., and Meinl, E. (2018). Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein. Ann Neurol, [Epub ahead of print].

Park, D.I., Stambuk, J., Razdorov, G., Pucic-Bakovic, M., Martins-de-Souza, D., Lauc, G., and Turck, C.W. (2018). Blood plasma/IgG N-glycome biosignatures associated with major depressive disorder symptom severity and the antidepressant response. Sci Rep 8, 179.

Weckmann, K., Diefenthaler, P., Baeken, M.W., Yusifli, K., Turck, C.W., Asara, J.M., Behl, C., and Hajieva, P. (2018). Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction. Sci Rep 8, 2337.

Keplinger, S., Beiderbeck, B., Michalakis, S., Biel, M., Grothe, B., and Kunz, L. (2018). Optogenetic Control of Neural Circuits in the Mongolian Gerbil. Front Cell Neurosci 12, 111.

Kozlowski, M., Corujo, D., Hothorn, M., Guberovic, I., Mandemaker, I.K., Blessing, C., Sporn, J., Gutierrez-Triana, A., Smith, R., Portmann, T., Treier, M., Scheffzek, K., Huet, S., Timinszky, G., Buschbeck, M., and Ladurner, A.G. (2018). MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms. EMBO Rep, [Epub ahead of print].

Durrbaum, M., Kruse, C., Nieken, K.J., Habermann, B., and Storchova, Z. (2018). The deregulated microRNAome contributes to the cellular response to aneuploidy. BMC Genomics 19, 197.

Frauenstein, A., and Meissner, F. (2018). Quantitative Proteomics of Secreted Proteins. Methods Mol Biol 1714, 215-227.

Mangal, S., Sacher, J., Kim, T., Osorio, D.S., Motegi, F., Carvalho, A.X., Oegema, K., and Zanin, E. (2018). TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis. J Cell Biol 217, 837-848.

Lemke, S.B., and Schnorrer, F. (2018). In Vivo Imaging of Muscle-tendon Morphogenesis in Drosophila Pupae. J Vis Exp, [Epub ahead of print].

Prytuliak, R., Pfeiffer, F., and Habermann, B.H. (2018). SLALOM, a flexible method for the identification and statistical analysis of overlapping continuous sequence elements in sequence- and time-series data. BMC Bioinformatics 19, 24.

Kabacaoglu, D., Ciecielski, K.J., Ruess, D.A., and Algul, H. (2018). Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options. Front Immunol 9, 1878.

Pakdel, M., and von Blume, J. (2018). Exploring new routes for secretory protein export from the trans-Golgi network. Mol Biol Cell 29, 235-240.

Scherr, M.J., Safaric, B., and Duderstadt, K.E. (2018). Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication. Bioessays 40.

Mucksch, J., Blumhardt, P., Strauss, M.T., Petrov, E.P., Jungmann, R., and Schwille, P. (2018). Quantifying Reversible Surface Binding via Surface-Integrated Fluorescence Correlation Spectroscopy. Nano Lett 18, 3185-3192.

Glock, P., Broichhagen, J., Kretschmer, S., Blumhardt, P., Mucksch, J., Trauner, D., and Schwille, P. (2018). Optical Control of a Biological Reaction-Diffusion System. Angew Chem Int Ed Engl 57, 2362-2366.

Ramm, B., Glock, P., and Schwille, P. (2018). In Vitro Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers. J Vis Exp, [Epub ahead of print].

Ramirez-Diaz, D.A., Garcia-Soriano, D.A., Raso, A., Mucksch, J., Feingold, M., Rivas, G., and Schwille, P. (2018). Treadmilling analysis reveals new insights into dynamic FtsZ ring architecture. PLoS Biol 16, e2004845.

Niederauer, C., Blumhardt, P., Mucksch, J., Heymann, M., Lambacher, A., and Schwille, P. (2018). Direct characterization of the evanescent field in objective-type total internal reflection fluorescence microscopy. Opt Express 26, 20492-20506.

Khmelinskaia, A., Mucksch, J., Conci, F., Chwastek, G., and Schwille, P. (2018). FCS Analysis of Protein Mobility on Lipid Monolayers. Biophys J 114, 2444-2454.

Loison, O., Weitkunat, M., Kaya-Copur, A., Nascimento Alves, C., Matzat, T., Spletter, M.L., Luschnig, S., Brasselet, S., Lenne, P.F., and Schnorrer, F. (2018). Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation. PLoS Biol 16, e2004718.

Ziegler, P.K., Bollrath, J., Pallangyo, C.K., Matsutani, T., Canli, O., De Oliveira, T., Diamanti, M.A., Muller, N., Gamrekelashvili, J., Putoczki, T., Horst, D., Mankan, A.K., Oner, M.G., Muller, S., Muller-Hocker, J., Kirchner, T., Slotta-Huspenina, J., Taketo, M.M., Reinheckel, T., Drose, S., Larner, A.C., Wels, W.S., Ernst, M., Greten, T.F., Arkan, M.C., Korn, T., Wirth, D., and Greten, F.R. (2018). Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell 174, 88-101 e16.

Moll, F., Walter, M., Rezende, F., Helfinger, V., Vasconez, E., De Oliveira, T., Greten, F.R., Olesch, C., Weigert, A., Radeke, H.H., and Schroder, K. (2018). NoxO1 Controls Proliferation of Colon Epithelial Cells. Front Immunol 9, 973.

Chen, N.P., Sun, Z., and Fassler, R. (2018). The Kank family proteins in adhesion dynamics. Curr Opin Cell Biol 54, 130-136.

Bratkovic, T., Modic, M., Camargo Ortega, G., Drukker, M., and Rogelj, B. (2018). Neuronal differentiation induces SNORD115 expression and is accompanied by post-transcriptional changes of serotonin receptor 2c mRNA. Sci Rep 8, 5101.

Weiler, S., Bauer, J., Hubener, M., Bonhoeffer, T., Rose, T., and Scheuss, V. (2018). High-yield in vitro recordings from neurons functionally characterized in vivo. Nat Protoc 13, 1275-1293.

Humphrey, S.J., Karayel, O., James, D.E., and Mann, M. (2018). High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform. Nat Protoc, [Epub ahead of print].

Schlichthaerle, T., Eklund, A., Schueder, F., Strauss, M., Tiede, C., Curd, A., Ries, J., Peckham, M., Tomlinson, D., and Jungmann, R. (2018). Site-specific labeling of Affimers for DNA-PAINT microscopy. Angew Chem Int Ed Engl, [Epub ahead of print].

Hussain, A., Zhang, M., Ucpunar, H.K., Svensson, T., Quillery, E., Gompel, N., Ignell, R., and Grunwald Kadow, I.C. (2018). Correction: Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines. PLoS Biol 16, e1002624.

Hussain, A., Pooryasin, A., Zhang, M., Loschek, L.F., La Fortezza, M., Friedrich, A.B., Blais, C.M., Ucpunar, H.K., Yepez, V.A., Lehmann, M., Gompel, N., Gagneur, J., Sigrist, S.J., and Grunwald Kadow, I.C. (2018). Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila. Elife 7.

Ensfelder, T.T., Kurz, M.Q., Iwan, K., Geiger, S., Matheisl, S., Muller, M., Beckmann, R., and Carell, T. (2018). ALKBH5-induced demethylation of mono- and dimethylated adenosine. Chem Commun (Camb) 54, 8591-8593.

Kveler, K., Starosvetsky, E., Ziv-Kenet, A., Kalugny, Y., Gorelik, Y., Shalev-Malul, G., Aizenbud-Reshef, N., Dubovik, T., Briller, M., Campbell, J., Rieckmann, J.C., Asbeh, N., Rimar, D., Meissner, F., Wiser, J., and Shen-Orr, S.S. (2018). Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed. Nat Biotechnol 36, 651-659,

Spletter, M.L., Barz, C., Yeroslaviz, A., Zhang, X., Lemke, S.B., Bonnard, A., Brunner, E., Cardone, G., Basler, K., Habermann, B.H., and Schnorrer, F. (2018). A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle. Elife 7.

La Fortezza, M., Grigolon, G., Cosolo, A., Pindyurin, A., Breimann, L., Blum, H., van Steensel, B., and Classen, A.K. (2018). DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis. Epigenetics Chromatin 11, 27.

Ruess, D.A., Heynen, G.J., Ciecielski, K.J., Ai, J., Berninger, A., Kabacaoglu, D., Gorgulu, K., Dantes, Z., Wormann, S.M., Diakopoulos, K.N., Karpathaki, A.F., Kowalska, M., Kaya-Aksoy, E., Song, L., van der Laan, E.A.Z., Lopez-Alberca, M.P., Nazare, M., Reichert, M., Saur, D., Erkan, M.M., Hopt, U.T., Sainz, B., Jr., Birchmeier, W., Schmid, R.M., Lesina, M., and Algul, H. (2018). Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med 24, 954-960.

Arzberger, T., Schludi, M.H., Lehmer, C., Schmid, B., and Edbauer, D. (2018). RNA versus protein toxicity in C9orf72 ALS/FTLD. Acta Neuropathol 135, 475-479.

Mosalaganti, S., Kosinski, J., Albert, S., Schaffer, M., Strenkert, D., Salome, P.A., Merchant, S.S., Plitzko, J.M., Baumeister, W., Engel, B.D., and Beck, M. (2018). In situ architecture of the algal nuclear pore complex. Nat Commun 9, 2361.

Strauss, S., Nickels, P.C., Strauss, M.T., Jimenez Sabinina, V., Ellenberg, J., Carter, J.D., Gupta, S., Janjic, N., and Jungmann, R. (2018). Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging. Nat Methods 15, 685-688.

Sinitcyn, P., Tiwary, S., Rudolph, J., Gutenbrunner, P., Wichmann, C., Yilmaz, S., Hamzeiy, H., Salinas, F., and Cox, J. (2018). MaxQuant goes Linux. Nat Methods 15, 401.

Gotzl, J.K., Colombo, A.V., Fellerer, K., Reifschneider, A., Werner, G., Tahirovic, S., Haass, C., and Capell, A. (2018). Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener 13, 48.

Blauwendraat, C., Wilke, C., Simon-Sanchez, J., Jansen, I.E., Reifschneider, A., Capell, A., Haass, C., Castillo-Lizardo, M., Biskup, S., Maetzler, W., Rizzu, P., Heutink, P., and Synofzik, M. (2018). The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects. Genet Med 20, 240-249.

Holze, C., Michaudel, C., Mackowiak, C., Haas, D.A., Benda, C., Hubel, P., Pennemann, F.L., Schnepf, D., Wettmarshausen, J., Braun, M., Leung, D.W., Amarasinghe, G.K., Perocchi, F., Staeheli, P., Ryffel, B., and Pichlmair, A. (2018). Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nat Immunol 19, 130-140.

Moretti, F.A., Klapproth, S., Ruppert, R., Margraf, A., Weber, J., Pick, R., Scheiermann, C., Sperandio, M., Fassler, R., and Moser, M. (2018). Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus. Elife 7.

Bache, N., Geyer, P.E., Bekker-Jensen, D.B., Hoerning, O., Falkenby, L., Treit, P.V., Doll, S., Paron, I., Muller, J.B., Meier, F., Olsen, J.V., Vorm, O., and Mann, M. (2018). A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics. Mol Cell Proteomics 17, 2284-2296.

Laprell, F., Finkl, K., and Muller, J. (2017). Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA. Science 356, 85-88.

Andreeva, L., Hiller, B., Kostrewa, D., Lassig, C., de Oliveira Mann, C.C., Jan Drexler, D., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., and Hopfner, K.P. (2017). cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature 549, 394-398.

Rieckmann, J.C., Geiger, R., Hornburg, D., Wolf, T., Kveler, K., Jarrossay, D., Sallusto, F., Shen-Orr, S.S., Lanzavecchia, A., Mann, M., and Meissner, F. (2017). Social network architecture of human immune cells unveiled by quantitative proteomics. Nat Immunol 18, 583-593.

Choi, J., Bachmann, A.L., Tauscher, K., Benda, C., Fierz, B., and Muller, J. (2017). DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation. Nat Struct Mol Biol 24, 1039-1047.

Lademann, C.A., Renkawitz, J., Pfander, B., and Jentsch, S. (2017). The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination. Cell Rep 19, 1294-1303.

Princz, L.N., Wild, P., Bittmann, J., Aguado, F.J., Blanco, M.G., Matos, J., and Pfander, B. (2017). Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis. EMBO J 36, 664-678.

di Cicco, G., Bantele, S.C.S., Reusswig, K.U., and Pfander, B. (2017). A cell cycle-independent mode of the Rad9-Dpb11 interaction is induced by DNA damage. Sci Rep 7, 11650.

Bantele, S.C., Ferreira, P., Gritenaite, D., Boos, D., and Pfander, B. (2017). Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection. Elife 6.

Lehmer, C., Oeckl, P., Weishaupt, J.H., Volk, A.E., Diehl-Schmid, J., Schroeter, M.L., Lauer, M., Kornhuber, J., Levin, J., Fassbender, K., Landwehrmeyer, B., Schludi, M.H., Arzberger, T., Kremmer, E., Flatley, A., Feederle, R., Steinacker, P., Weydt, P., Ludolph, A.C., Edbauer, D., and Otto, M. (2017). Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD. EMBO Mol Med 9, 859-868.

Varga, J., and Greten, F.R. (2017). Cell plasticity in epithelial homeostasis and tumorigenesis. Nat Cell Biol 19, 1133-1141.

Li, L., Lingaraju, M., Basquin, C., Basquin, J., and Conti, E. (2017). Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins. RNA 23, 1028-1034.

Laprell, L., Tochitsky, I., Kaur, K., Manookin, M.B., Stein, M., Barber, D.M., Schon, C., Michalakis, S., Biel, M., Kramer, R.H., Sumser, M.P., Trauner, D., and Van Gelder, R.N. (2017). Photopharmacological control of bipolar cells restores visual function in blind mice. J Clin Invest 127, 2598-2611.

Sahasrabudhe, P., Rohrberg, J., Biebl, M.M., Rutz, D.A., and Buchner, J. (2017). The Plasticity of the Hsp90 Co-chaperone System. Mol Cell 67, 947-961 e945.

Schopf, F.H., Biebl, M.M., and Buchner, J. (2017). The HSP90 chaperone machinery. Nat Rev Mol Cell Biol 18, 345-360.

Pasalic, D., Weber, B., Giannone, C., Anelli, T., Muller, R., Fagioli, C., Felkl, M., John, C., Mossuto, M.F., Becker, C.F.W., Sitia, R., and Buchner, J. (2017). A peptide extension dictates IgM assembly. Proc Natl Acad Sci U S A 114, E8575-E8584.

Matscheko, N., Mayrhofer, P., and Wollert, T. (2017). Passing membranes to autophagy: Unconventional membrane tethering by Atg17. Autophagy 13, 629-630.

Zhang, X., and Schnorrer, F. (2017). AIDing-targeted protein degradation in Drosophila. FEBS J 284, 1178-1181.

Weitkunat, M., Brasse, M., Bausch, A.R., and Schnorrer, F. (2017). Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscle in vivo. Development 144, 1261-1272.

Lemke, S.B., and Schnorrer, F. (2017). Mechanical forces during muscle development. Mech Dev 144, 92-101.

Balsevich, G., Hausl, A.S., Meyer, C.W., Karamihalev, S., Feng, X., Pohlmann, M.L., Dournes, C., Uribe-Marino, A., Santarelli, S., Labermaier, C., Hafner, K., Mao, T., Breitsamer, M., Theodoropoulou, M., Namendorf, C., Uhr, M., Paez-Pereda, M., Winter, G., Hausch, F., Chen, A., Tschop, M.H., Rein, T., Gassen, N.C., and Schmidt, M.V. (2017). Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. Nat Commun 8, 1725.

Weckmann, K., Deery, M.J., Howard, J.A., Feret, R., Asara, J.M., Dethloff, F., Filiou, M.D., Iannace, J., Labermaier, C., Maccarrone, G., Webhofer, C., Teplytska, L., Lilley, K., Muller, M.B., and Turck, C.W. (2017). Ketamine's antidepressant effect is mediated by energy metabolism and antioxidant defense system. Sci Rep 7, 15788.

Santarelli, S., Zimmermann, C., Kalideris, G., Lesuis, S.L., Arloth, J., Uribe, A., Dournes, C., Balsevich, G., Hartmann, J., Masana, M., Binder, E.B., Spengler, D., and Schmidt, M.V. (2017). An adverse early life environment can enhance stress resilience in adulthood. Psychoneuroendocrinology 78, 213-221.

Balaji, R., Bielmeier, C., Harz, H., Bates, J., Stadler, C., Hildebrand, A., and Classen, A.K. (2017). Calcium spikes, waves and oscillations in a large, patterned epithelial tissue. Sci Rep 7, 42786.

Wilhelm, L., and Gruber, S. (2017). A Chromosome Co-Entrapment Assay to Study Topological Protein-DNA Interactions. Methods Mol Biol 1624, 117-126.

Sherrard, R., Luehr, S., Holzkamp, H., McJunkin, K., Memar, N., and Conradt, B. (2017). miRNAs cooperate in apoptosis regulation during C. elegans development. Genes Dev 31, 209-222.

Punzeler, S., Link, S., Wagner, G., Keilhauer, E.C., Kronbeck, N., Spitzer, R.M., Leidescher, S., Markaki, Y., Mentele, E., Regnard, C., Schneider, K., Takahashi, D., Kusakabe, M., Vardabasso, C., Zink, L.M., Straub, T., Bernstein, E., Harata, M., Leonhardt, H., Mann, M., Rupp, R.A., and Hake, S.B. (2017). Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. EMBO J 36, 2263-2279.

Freikamp, A., Mehlich, A., Klingner, C., and Grashoff, C. (2017). Investigating piconewton forces in cells by FRET-based molecular force microscopy. J Struct Biol 197, 37-42.

Albert, S., Schaffer, M., Beck, F., Mosalaganti, S., Asano, S., Thomas, H.F., Plitzko, J.M., Beck, M., Baumeister, W., and Engel, B.D. (2017). Proteasomes tether to two distinct sites at the nuclear pore complex. Proc Natl Acad Sci U S A 114, 13726-13731.

Thanisch, K., Song, C., Engelkamp, D., Koch, J., Wang, A., Hallberg, E., Foisner, R., Leonhardt, H., Stewart, C.L., Joffe, B., and Solovei, I. (2017). Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering. Differentiation 94, 58-70.

Karg, E., Smets, M., Ryan, J., Forne, I., Qin, W., Mulholland, C.B., Kalideris, G., Imhof, A., Bultmann, S., and Leonhardt, H. (2017). Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells. J Mol Biol 429, 3814-3824.

Thoma, V., Kobayashi, K., and Tanimoto, H. (2017). The Role of the Gustatory System in the Coordination of Feeding. eNeuro 4.

Prytuliak, R., Volkmer, M., Meier, M., and Habermann, B.H. (2017). HH-MOTiF: de novo detection of short linear motifs in proteins by Hidden Markov Model comparisons. Nucleic Acids Res 45, W470-W477.

Hamzeiy, H., and Cox, J. (2017). What computational non-targeted mass spectrometry-based metabolomics can gain from shotgun proteomics. Curr Opin Biotechnol 43, 141-146.

Jonak, K., Zagoriy, I., Oz, T., Graf, P., Rojas, J., Mengoli, V., and Zachariae, W. (2017). APC/C-Cdc20 mediates deprotection of centromeric cohesin at meiosis II in yeast. Cell Cycle 16, 1145-1152.

Arguello-Miranda, O., Zagoriy, I., Mengoli, V., Rojas, J., Jonak, K., Oz, T., Graf, P., and Zachariae, W. (2017). Casein Kinase 1 Coordinates Cohesin Cleavage, Gametogenesis, and Exit from M Phase in Meiosis II. Dev Cell 40, 37-52.

Geyer, P.E., Holdt, L.M., Teupser, D., and Mann, M. (2017). Revisiting biomarker discovery by plasma proteomics. Mol Syst Biol 13, 942.

Kremer, M.C., Jung, C., Batelli, S., Rubin, G.M., and Gaul, U. (2017). The glia of the adult Drosophila nervous system. Glia 65, 606-638.

Batelli, S., Kremer, M., Jung, C., and Gaul, U. (2017). Application of MultiColor FlpOut Technique to Study High Resolution Single Cell Morphologies and Cell Interactions of Glia in Drosophila. J Vis Exp., 128.

Bhat, J.Y., Milicic, G., Thieulin-Pardo, G., Bracher, A., Maxwell, A., Ciniawsky, S., Mueller-Cajar, O., Engen, J.R., Hartl, F.U., Wendler, P., and Hayer-Hartl, M. (2017). Mechanism of Enzyme Repair by the AAA+ Chaperone Rubisco Activase. Mol Cell 67, 744-756 e746.

Bauerlein, F.J.B., Saha, I., Mishra, A., Kalemanov, M., Martinez-Sanchez, A., Klein, R., Dudanova, I., Hipp, M.S., Hartl, F.U., Baumeister, W., and Fernandez-Busnadiego, R. (2017). In Situ Architecture and Cellular Interactions of PolyQ Inclusions. Cell 171, 179-187 e110.

Hosp, F., Gutierrez-Angel, S., Schaefer, M.H., Cox, J., Meissner, F., Hipp, M.S., Hartl, F.U., Klein, R., Dudanova, I., and Mann, M. (2017). Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function. Cell Rep 21, 2291-2303.

Del Toro, D., Ruff, T., Cederfjall, E., Villalba, A., Seyit-Bremer, G., Borrell, V., and Klein, R. (2017). Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules. Cell 169, 621-635.e616.

Douglass, A.M., Kucukdereli, H., Ponserre, M., Markovic, M., Grundemann, J., Strobel, C., Alcala Morales, P.L., Conzelmann, K.K., Luthi, A., and Klein, R. (2017). Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nat Neurosci 20, 1384-1394.

Hunt, S., Sun, Y., Kucukdereli, H., Klein, R., and Sah, P. (2017). Intrinsic Circuits in the Lateral Central Amygdala. eNeuro 4.

Nilsson, O.B., Nickson, A.A., Hollins, J.J., Wickles, S., Steward, A., Beckmann, R., von Heijne, G., and Clarke, J. (2017). Cotranslational folding of spectrin domains via partially structured states. Nat Struct Mol Biol 24, 221-225.

Diamanti, M.A., Gupta, J., Bennecke, M., De Oliveira, T., Ramakrishnan, M., Braczynski, A.K., Richter, B., Beli, P., Hu, Y., Saleh, M., Mittelbronn, M., Dikic, I., and Greten, F.R. (2017). IKKalpha controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med 214, 423-437.

Smets, M., Link, S., Wolf, P., Schneider, K., Solis, V., Ryan, J., Meilinger, D., Qin, W., and Leonhardt, H. (2017). DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. Hum Mol Genet 26, 1522-1534.

van de Werken, H.J.G., Haan, J.C., Feodorova, Y., Bijos, D., Weuts, A., Theunis, K., Holwerda, S.J.B., Meuleman, W., Pagie, L., Thanisch, K., Kumar, P., Leonhardt, H., Marynen, P., van Steensel, B., Voet, T., de Laat, W., Solovei, I., and Joffe, B. (2017). Small chromosomal regions position themselves autonomously according to their chromatin class. Genome Res 27, 922-933.

Bottcher, R.T., Sun, Z., and Fassler, R. (2017). A forceful connection: mechanoregulation of oncogenic YAP. EMBO J 36, 2467-2469.

Kulak, N.A., Geyer, P.E., and Mann, M. (2017). Loss-less Nano-fractionator for High Sensitivity, High Coverage Proteomics. Mol Cell Proteomics 16, 694-705.

Doll, S., Dressen, M., Geyer, P.E., Itzhak, D.N., Braun, C., Doppler, S.A., Meier, F., Deutsch, M.A., Lahm, H., Lange, R., Krane, M., and Mann, M. (2017). Region and cell-type resolved quantitative proteomic map of the human heart. Nat Commun 8, 1469.

Fischer, J.C., Otten, V., Kober, M., Drees, C., Rosenbaum, M., Schmickl, M., Heidegger, S., Beyaert, R., van Loo, G., Li, X.C., Peschel, C., Schmidt-Supprian, M., Haas, T., Spoerl, S., and Poeck, H. (2017). A20 Restrains Thymic Regulatory T Cell Development. J Immunol 199, 2356-2365.

Kyratsous, N.I., Bauer, I.J., Zhang, G., Pesic, M., Bartholomaus, I., Mues, M., Fang, P., Worner, M., Everts, S., Ellwart, J.W., Watt, J.M., Potter, B.V.L., Hohlfeld, R., Wekerle, H., and Kawakami, N. (2017). Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proc Natl Acad Sci U S A 114, E6381-E6389.

Carrillo-Roa, T., Labermaier, C., Weber, P., Herzog, D.P., Lareau, C., Santarelli, S., Wagner, K.V., Rex-Haffner, M., Harbich, D., Scharf, S.H., Nemeroff, C.B., Dunlop, B.W., Craighead, W.E., Mayberg, H.S., Schmidt, M.V., Uhr, M., Holsboer, F., Sillaber, I., Binder, E.B., and Muller, M.B. (2017). Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity. PLoS Biol 15, e2002690.

Cammareri, P., Vincent, D.F., Hodder, M.C., Ridgway, R.A., Murgia, C., Nobis, M., Campbell, A.D., Varga, J., Huels, D.J., Subramani, C., Prescott, K.L.H., Nixon, C., Hedley, A., Barry, S.T., Greten, F.R., Inman, G.J., and Sansom, O.J. (2017). TGFbeta pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death Differ 24, 1681-1693.

Zink, L.M., Delbarre, E., Eberl, H.C., Keilhauer, E.C., Bonisch, C., Punzeler, S., Bartkuhn, M., Collas, P., Mann, M., and Hake, S.B. (2017). H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements. Nucleic Acids Res 45, 5691-5706.

Loose, M., Zieske, K., and Schwille, P. (2017). Reconstitution of Protein Dynamics Involved in Bacterial Cell Division. Subcell Biochem 84, 419-444.

Kretschmer, S., Zieske, K., and Schwille, P. (2017). Large-scale modulation of reconstituted Min protein patterns and gradients by defined mutations in MinE's membrane targeting sequence. PLoS One 12, e0179582.

Aigner, H., Wilson, R.H., Bracher, A., Calisse, L., Bhat, J.Y., Hartl, F.U., and Hayer-Hartl, M. (2017). Plant RuBisCo assembly in E. coli with five chloroplast chaperones including BSD2. Science 358, 1272-1278.

Gaidt, M.M., Ebert, T.S., Chauhan, D., Ramshorn, K., Pinci, F., Zuber, S., O'Duill, F., Schmid-Burgk, J.L., Hoss, F., Buhmann, R., Wittmann, G., Latz, E., Subklewe, M., and Hornung, V. (2017). The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell 171, 1110-1124 e1118.

Ringer, P., Weissl, A., Cost, A.L., Freikamp, A., Sabass, B., Mehlich, A., Tramier, M., Rief, M., and Grashoff, C. (2017). Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1. Nat Methods 14, 1090-1096.

Burmann, F., Basfeld, A., Vazquez Nunez, R., Diebold-Durand, M.L., Wilhelm, L., and Gruber, S. (2017). Tuned SMC Arms Drive Chromosomal Loading of Prokaryotic Condensin. Mol Cell 65, 861-872 e869.

Gebhardt, A., Laudenbach, B.T., and Pichlmair, A. (2017). Discrimination of Self and Non-Self Ribonucleic Acids. J Interferon Cytokine Res 37, 184-197.

Abbas, Y.M., Laudenbach, B.T., Martinez-Montero, S., Cencic, R., Habjan, M., Pichlmair, A., Damha, M.J., Pelletier, J., and Nagar, B. (2017). Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc Natl Acad Sci U S A 114, E2106-E2115.

Knogler, L.D., Markov, D.A., Dragomir, E.I., Stih, V., and Portugues, R. (2017). Sensorimotor Representations in Cerebellar Granule Cells in Larval Zebrafish Are Dense, Spatially Organized, and Non-temporally Patterned. Curr Biol 27, 1288-1302.

Schueder, F., Strauss, M.T., Hoerl, D., Schnitzbauer, J., Schlichthaerle, T., Strauss, S., Yin, P., Harz, H., Leonhardt, H., and Jungmann, R. (2017). Universal Super-Resolution Multiplexing by DNA Exchange. Angew Chem Int Ed Engl 56, 4052-4055.

Schnitzbauer, J., Strauss, M.T., Schlichthaerle, T., Schueder, F., and Jungmann, R. (2017). Super-resolution microscopy with DNA-PAINT. Nat Protoc 12, 1198-1228.

Woehrstein, J.B., Strauss, M.T., Ong, L.L., Wei, B., Zhang, D.Y., Jungmann, R., and Yin, P. (2017). Sub-100-nm metafluorophores with digitally tunable optical properties self-assembled from DNA. Sci Adv 3, e1602128.

Schueder, F., Lara-Gutierrez, J., Beliveau, B.J., Saka, S.K., Sasaki, H.M., Woehrstein, J.B., Strauss, M.T., Grabmayr, H., Yin, P., and Jungmann, R. (2017). Multiplexed 3D super-resolution imaging of whole cells using spinning disk confocal microscopy and DNA-PAINT. Nat Commun 8, 2090.

Ong, L.L., Hanikel, N., Yaghi, O.K., Grun, C., Strauss, M.T., Bron, P., Lai-Kee-Him, J., Schueder, F., Wang, B., Wang, P., Kishi, J.Y., Myhrvold, C., Zhu, A., Jungmann, R., Bellot, G., Ke, Y., and Yin, P. (2017). Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components. Nature 552, 72-77.

Auer, A., Strauss, M.T., Schlichthaerle, T., and Jungmann, R. (2017). Fast, background-free DNA-PAINT imaging using FRET-based probes. Nano Lett 17, 6428-6434.

Pfeffer, S., Dudek, J., Schaffer, M., Ng, B.G., Albert, S., Plitzko, J.M., Baumeister, W., Zimmermann, R., Freeze, H.H., Engel, B.D., and Forster, F. (2017). Dissecting the molecular organization of the translocon-associated protein complex. Nat Commun 8, 14516.

Bykov, Y.S., Schaffer, M., Dodonova, S.O., Albert, S., Plitzko, J.M., Baumeister, W., Engel, B.D., and Briggs, J.A. (2017). The structure of the COPI coat determined within the cell. Elife 6.

Scilabra, S.D., Yamamoto, K., Pigoni, M., Sakamoto, K., Muller, S.A., Papadopoulou, A., Lichtenthaler, S.F., Troeberg, L., Nagase, H., and Kadomatsu, K. (2017). Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue. Matrix Biol 59, 69-79.

Kleinberger, G., Brendel, M., Mracsko, E., Wefers, B., Groeneweg, L., Xiang, X., Focke, C., Deussing, M., Suarez-Calvet, M., Mazaheri, F., Parhizkar, S., Pettkus, N., Wurst, W., Feederle, R., Bartenstein, P., Mueggler, T., Arzberger, T., Knuesel, I., Rominger, A., and Haass, C. (2017). The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J 36, 1837-1853.

Singh, H.R., Nardozza, A.P., Moller, I.R., Knobloch, G., Kistemaker, H.A.V., Hassler, M., Harrer, N., Blessing, C., Eustermann, S., Kotthoff, C., Huet, S., Mueller-Planitz, F., Filippov, D.V., Timinszky, G., Rand, K.D., and Ladurner, A.G. (2017). A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene. Mol Cell 68, 860-871.e867.

Steger, M., Diez, F., Dhekne, H.S., Lis, P., Nirujogi, R.S., Karayel, O., Tonelli, F., Martinez, T.N., Lorentzen, E., Pfeffer, S.R., Alessi, D.R., and Mann, M. (2017). Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. Elife 6.

Druzd, D., Matveeva, O., Ince, L., Harrison, U., He, W., Schmal, C., Herzel, H., Tsang, A.H., Kawakami, N., Leliavski, A., Uhl, O., Yao, L., Sander, L.E., Chen, C.S., Kraus, K., de Juan, A., Hergenhan, S.M., Ehlers, M., Koletzko, B., Haas, R., Solbach, W., Oster, H., and Scheiermann, C. (2017). Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Immunity 46, 120-132.

Ludwig, A.K., Zhang, P., Hastert, F.D., Meyer, S., Rausch, C., Herce, H.D., Muller, U., Lehmkuhl, A., Hellmann, I., Trummer, C., Storm, C., Leonhardt, H., and Cardoso, M.C. (2017). Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise. Nucleic Acids Res 45, 2438-2457.

Woerner, A.C., Frottin, F., Hornburg, D., Feng, L.R., Meissner, F., Patra, M., Tatzelt, J., Mann, M., Winklhofer, K.F., Hartl, F.U., and Hipp, M.S. (2016). Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science 351, 173-176.

Falkner, S., Grade, S., Dimou, L., Conzelmann, K.K., Bonhoeffer, T., Gotz, M., and Hubener, M. (2016). Transplanted embryonic neurons integrate into adult neocortical circuits. Nature 539, 248-253.

Kornprobst, M., Turk, M., Kellner, N., Cheng, J., Flemming, D., Kos-Braun, I., Kos, M., Thoms, M., Berninghausen, O., Beckmann, R., and Hurt, E. (2016). Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome. Cell 166, 380-393.

Coscia, F., Watters, K.M., Curtis, M., Eckert, M.A., Chiang, C.Y., Tyanova, S., Montag, A., Lastra, R.R., Lengyel, E., and Mann, M. (2016). Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status. Nat Commun 7, 12645.

Gascon, S., Murenu, E., Masserdotti, G., Ortega, F., Russo, G.L., Petrik, D., Deshpande, A., Heinrich, C., Karow, M., Robertson, S.P., Schroeder, T., Beckers, J., Irmler, M., Berndt, C., Angeli, J.P., Conrad, M., Berninger, B., and Gotz, M. (2016). Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming. Cell Stem Cell 18, 396-409.

Geiger, R., Rieckmann, J.C., Wolf, T., Basso, C., Feng, Y., Fuhrer, T., Kogadeeva, M., Picotti, P., Meissner, F., Mann, M., Zamboni, N., Sallusto, F., and Lanzavecchia, A. (2016). L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell 167, 829-842 e813

Neudegger, T., Verghese, J., Hayer-Hartl, M., Hartl, F.U., and Bracher, A. (2016). Structure of human heat-shock transcription factor 1 in complex with DNA. Nat Struct Mol Biol 23, 140-146.

Varga, J., and Greten, F.R. (2016). Lifting the Mist on Gastric Stem Cells. Cell Stem Cell 18, 7-9.

Sun, Z., Tseng, H.Y., Tan, S., Senger, F., Kurzawa, L., Dedden, D., Mizuno, N., Wasik, A.A., Thery, M., Dunn, A.R., and Fassler, R. (2016). Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation. Nat Cell Biol 18, 941-953.

Sun, Z., Guo, S.S., and Fassler, R. (2016). Integrin-mediated mechanotransduction. J Cell Biol 215, 445-456.

Thoma, V., Knapek, S., Arai, S., Hartl, M., Kohsaka, H., Sirigrivatanawong, P., Abe, A., Hashimoto, K., and Tanimoto, H. (2016). Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila. Nat Commun 7, 10678.

Park, D.I., Dournes, C., Sillaber, I., Uhr, M., Asara, J.M., Gassen, N.C., Rein, T., Ising, M., Webhofer, C., Filiou, M.D., Muller, M.B., and Turck, C.W. (2016). Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans. Sci Rep 6, 35317.

Liebscher, S., Keller, G.B., Goltstein, P.M., Bonhoeffer, T., and Hubener, M. (2016). Selective Persistence of Sensorimotor Mismatch Signals in Visual Cortex of Behaving Alzheimer's Disease Mice. Curr Biol 26, 956-964.

Asano, S., Engel, B.D., and Baumeister, W. (2016). In Situ Cryo-Electron Tomography: A Post-Reductionist Approach to Structural Biology. J Mol Biol 428, 332-343.

Freikamp, A., Mehlich, A., Klingner, C., and Grashoff, C. (2016). Investigating piconewton forces in cells by FRET-based molecular force microscopy. J Struct Biol, 197, 37-42.

Freikamp, A., Cost, A.L., and Grashoff, C. (2016). The Piconewton Force Awakens: Quantifying Mechanics in Cells. Trends Cell Biol, 26, 838-847.

Spadaro, M., Gerdes, L.A., Krumbholz, M., Ertl-Wagner, B., Thaler, F.S., Schuh, E., Metz, I., Blaschek, A., Dick, A., Bruck, W., Hohlfeld, R., Meinl, E., and Kumpfel, T. (2016). Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 3, e257.

Spadaro, M., and Meinl, E. (2016). Detection of Autoantibodies Against Myelin Oligodendrocyte Glycoprotein in Multiple Sclerosis and Related Diseases. Methods Mol Biol 1304, 99-104.

Durrbaum, M., and Storchova, Z. (2016). Effects of aneuploidy on gene expression: implications for cancer. FEBS J 283, 791-802.

Schmidtmann, E., Anton, T., Rombaut, P., Herzog, F., and Leonhardt, H. (2016). Determination of local chromatin composition by CasID. Nucleus, 1-9.

Geyer, P.E., Kulak, N.A., Pichler, G., Holdt, L.M., Teupser, D., and Mann, M. (2016). Plasma Proteome Profiling to Assess Human Health and Disease. Cell Syst 2, 185-195.

Nokwe, C.N., Hora, M., Zacharias, M., Yagi, H., Peschek, J., Reif, B., Goto, Y., and Buchner, J. (2016). A Stable Mutant Predisposes Antibody Domains to Amyloid Formation through Specific Non-Native Interactions. J Mol Biol 428, 1315-1332.

Santarelli, S., Wagner, K.V., Labermaier, C., Uribe, A., Dournes, C., Balsevich, G., Hartmann, J., Masana, M., Holsboer, F., Chen, A., Muller, M.B., and Schmidt, M.V. (2016). SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Stress 19, 83-90.

Balsevich, G., Baumann, V., Uribe, A., Chen, A., and Schmidt, M.V. (2016). Prenatal Exposure to Maternal Obesity Alters Anxiety and Stress Coping Behaviors in Aged Mice. Neuroendocrinology 103, 354-368.

Reuter, L.M., and Strasser, K. (2016). Falling for the dark side of transcription: Nab2 fosters RNA polymerase III transcription. Transcription 7, 69-74.

Laprell, L., Hull, K., Stawski, P., Schon, C., Michalakis, S., Biel, M., Sumser, M.P., and Trauner, D. (2016). Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist. ACS Chem Neurosci 7, 15-20.

Psakhye, I., and Jentsch, S. (2016). Identification of Substrates of Protein-Group SUMOylation. Methods Mol Biol 1475, 219-231.

Gruner, B.M., Winkelmann, I., Feuchtinger, A., Sun, N., Balluff, B., Teichmann, N., Herner, A., Kalideris, E., Steiger, K., Braren, R., Aichler, M., Esposito, I., Schmid, R.M., Walch, A., and Siveke, J.T. (2016). Modeling Therapy Response and Spatial Tissue Distribution of Erlotinib in Pancreatic Cancer. Mol Cancer Ther 15, 1145-1152.

Zieske, K., Chwastek, G., and Schwille, P. (2016). Protein Patterns and Oscillations on Lipid Monolayers and in Microdroplets. Angew Chem Int Ed Engl, 55, 13455-13459.

Ramesh, V., Bayam, E., Cernilogar, F.M., Bonapace, I.M., Schulze, M., Riemenschneider, M.J., Schotta, G., and Gotz, M. (2016). Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration. Genes Dev 30, 2199-2212

Borner, K., Jain, D., Vazquez-Pianzola, P., Vengadasalam, S., Steffen, N., Fyodorov, D.V., Tomancak, P., Konev, A., Suter, B., and Becker, P.B. (2016). A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis. Dev Biol 411, 217-230.

Peleg, S., Feller, C., Forne, I., Schiller, E., Sevin, D.C., Schauer, T., Regnard, C., Straub, T., Prestel, M., Klima, C., Schmitt Nogueira, M., Becker, L., Klopstock, T., Sauer, U., Becker, P.B., Imhof, A., and Ladurner, A.G. (2016). Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. EMBO Rep 17, 455-469.

Blasi, T., Feller, C., Feigelman, J., Hasenauer, J., Imhof, A., Theis, F.J., Becker, P.B., and Marr, C. (2016). Combinatorial Histone Acetylation Patterns Are Generated by Motif-Specific Reactions. Cell Syst 2, 49-58.

Peleg, S., Feller, C., Ladurner, A.G., and Imhof, A. (2016). The Metabolic Impact on Histone Acetylation and Transcription in Ageing. Trends Biochem Sci 41, 700-711.

Greiss, F., Deligiannaki, M., Jung, C., Gaul, U., and Braun, D. (2016). Single-Molecule Imaging in Living Drosophila Embryos with Reflected Light-Sheet Microscopy. Biophys J 110, 939-946.

Schneider, M., Rosam, M., Glaser, M., Patronov, A., Shah, H., Back, K.C., Daake, M.A., Buchner, J., and Antes, I. (2016). BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP. Proteins, 84, 1390-1407.

Hussain, A., Ucpunar, H.K., Zhang, M., Loschek, L.F., and Grunwald Kadow, I.C. (2016). Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila. PLoS Biol 14, e1002455.

Hussain, A., Zhang, M., Ucpunar, H.K., Svensson, T., Quillery, E., Gompel, N., Ignell, R., and Grunwald Kadow, I.C. (2016). Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines. PLoS Biol 14, e1002454.

Taschner, M., Weber, K., Mourao, A., Vetter, M., Awasthi, M., Stiegler, M., Bhogaraju, S., and Lorentzen, E. (2016). Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex. EMBO J 35, 773-790.

Sellou, H., Lebeaupin, T., Chapuis, C., Smith, R., Hegele, A., Singh, H.R., Kozlowski, M., Bultmann, S., Ladurner, A.G., Timinszky, G., and Huet, S. (2016). The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage. Mol Biol Cell, 27, 3791-3799.

Rao, Y., Matscheko, N., and Wollert, T. (2016). Autophagy in the test tube: In vitro reconstitution of aspects of autophagosome biogenesis. FEBS J 283, 2034-2043.

Hidalgo-Sastre, A., Brodylo, R.L., Lubeseder-Martellato, C., Sipos, B., Steiger, K., Lee, M., von Figura, G., Grunwald, B., Zhong, S., Trajkovic-Arsic, M., Neff, F., Schmid, R.M., and Siveke, J.T. (2016). Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model. Am J Pathol 186, 2934-2944

Lubeseder-Martellato, C., Hidalgo-Sastre, A., Hartmann, C., Alexandrow, K., Kamyabi-Moghaddam, Z., Sipos, B., Wirth, M., Neff, F., Reichert, M., Heid, I., Schneider, G., Braren, R., Schmid, R.M., and Siveke, J.T. (2016). Membranous CD24 drives the epithelial phenotype of pancreatic cancer. Oncotarget, 7, 49156-49168.

Sivadasan, R., Hornburg, D., Drepper, C., Frank, N., Jablonka, S., Hansel, A., Lojewski, X., Sterneckert, J., Hermann, A., Shaw, P.J., Ince, P.G., Mann, M., Meissner, F., and Sendtner, M. (2016). C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. Nat Neurosci 19, 1610-1618.

Schwenk, B.M., Hartmann, H., Serdaroglu, A., Schludi, M.H., Hornburg, D., Meissner, F., Orozco, D., Colombo, A., Tahirovic, S., Michaelsen, M., Schreiber, F., Haupt, S., Peitz, M., Brustle, O., Kupper, C., Klopstock, T., Otto, M., Ludolph, A.C., Arzberger, T., Kuhn, P.H., and Edbauer, D. (2016). TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. EMBO J 35, 2350-2370.

Mori, K., Nihei, Y., Arzberger, T., Zhou, Q., Mackenzie, I.R., Hermann, A., Hanisch, F., German Consortium for Frontotemporal Lobar, D., Bavarian Brain Banking, A., Kamp, F., Nuscher, B., Orozco, D., Edbauer, D., and Haass, C. (2016). Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition. EMBO Rep 17, 1314-1325.

Vos, S.M., Pollmann, D., Caizzi, L., Hofmann, K.B., Rombaut, P., Zimniak, T., Herzog, F., and Cramer, P. (2016). Architecture and RNA binding of the human negative elongation factor. Elife 5.

Uribe-Marino, A., Gassen, N.C., Wiesbeck, M.F., Balsevich, G., Santarelli, S., Solfrank, B., Dournes, C., Fries, G.R., Masana, M., Labermeier, C., Wang, X.D., Hafner, K., Schmid, B., Rein, T., Chen, A., Deussing, J.M., and Schmidt, M.V. (2016). Prefrontal Cortex Corticotropin-Releasing Factor Receptor 1 Conveys Acute Stress-Induced Executive Dysfunction. Biol Psychiatry, 80, 743-753.

Zheng, X., Ramani, A., Soni, K., Gottardo, M., Zheng, S., Ming Gooi, L., Li, W., Feng, S., Mariappan, A., Wason, A., Widlund, P., Pozniakovsky, A., Poser, I., Deng, H., Ou, G., Riparbelli, M., Giuliano, C., Hyman, A.A., Sattler, M., Gopalakrishnan, J., and Li, H. (2016). Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length. Nat Commun 7, 11874.

McShane, E., Sin, C., Zauber, H., Wells, J.N., Donnelly, N., Wang, X., Hou, J., Chen, W., Storchova, Z., Marsh, J.A., Valleriani, A., and Selbach, M. (2016). Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation. Cell 167, 803-815 e821.

Passerini, V., Ozeri-Galai, E., de Pagter, M.S., Donnelly, N., Schmalbrock, S., Kloosterman, W.P., Kerem, B., and Storchova, Z. (2016). The presence of extra chromosomes leads to genomic instability. Nat Commun 7, 10754.

Choe, Y.J., Park, S.H., Hassemer, T., Korner, R., Vincenz-Donnelly, L., Hayer-Hartl, M., and Hartl, F.U. (2016). Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature 531, 191-195.

Canli, O., Alankus, Y.B., Grootjans, S., Vegi, N., Hultner, L., Hoppe, P.S., Schroeder, T., Vandenabeele, P., Bornkamm, G.W., and Greten, F.R. (2016). Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors. Blood 127, 139-148.

Kedrov, A., Wickles, S., Crevenna, A.H., van der Sluis, E.O., Buschauer, R., Berninghausen, O., Lamb, D.C., and Beckmann, R. (2016). Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis. Cell Rep 17, 2943-2954.

Lassig, C., Matheisl, S., Sparrer, K.M., de Oliveira Mann, C.C., Moldt, M., Patel, J.R., Goldeck, M., Hartmann, G., Garcia-Sastre, A., Hornung, V., Conzelmann, K.K., Beckmann, R., and Hopfner, K.P. (2016). Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. Elife 5.

Barber, D.M., Schonberger, M., Burgstaller, J., Levitz, J., Weaver, C.D., Isacoff, E.Y., Baier, H., and Trauner, D. (2016). Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO). Chem Sci 7, 2347-2352.

Trads, J.B., Burgstaller, J., Laprell, L., Konrad, D.B., de la Osa de la Rosa, L., Weaver, C.D., Baier, H., Trauner, D., and Barber, D.M. (2016). Optical control of GIRK channels using visible light. Org Biomol Chem 15, 76-81.

Zierer, B.K., Rubbelke, M., Tippel, F., Madl, T., Schopf, F.H., Rutz, D.A., Richter, K., Sattler, M., and Buchner, J. (2016). Importance of cycle timing for the function of the molecular chaperone Hsp90. Nat Struct Mol Biol 23, 1020-1028.

La Fortezza, M., Schenk, M., Cosolo, A., Kolybaba, A., Grass, I., and Classen, A.K. (2016). JAK/STAT signalling mediates cell survival in response to tissue stress. Development 143, 2907-2919.

Schwab, N., Schneider-Hohendorf, T., Pignolet, B., Spadaro, M., Gorlich, D., Meinl, I., Windhagen, S., Tackenberg, B., Breuer, J., Canto, E., Kumpfel, T., Hohlfeld, R., Siffrin, V., Luessi, F., Posevitz-Fejfar, A., Montalban, X., Meuth, S.G., Zipp, F., Gold, R., Du Pasquier, R.A., Kleinschnitz, C., Jacobi, A., Comabella, M., Bertolotto, A., Brassat, D., and Wiendl, H. (2016). PML risk stratification using anti-JCV antibody index and L-selectin. Mult Scler 22, 1048-1060.

Gross, C.C., Schulte-Mecklenbeck, A., Runzi, A., Kuhlmann, T., Posevitz-Fejfar, A., Schwab, N., Schneider-Hohendorf, T., Herich, S., Held, K., Konjevic, M., Hartwig, M., Dornmair, K., Hohlfeld, R., Ziemssen, T., Klotz, L., Meuth, S.G., and Wiendl, H. (2016). Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A 113, E2973-2982.

Wormann, S.M., Song, L., Ai, J., Diakopoulos, K.N., Kurkowski, M.U., Gorgulu, K., Ruess, D., Campbell, A., Doglioni, C., Jodrell, D., Neesse, A., Demir, I.E., Karpathaki, A.P., Barenboim, M., Hagemann, T., Rose-John, S., Sansom, O., Schmid, R.M., Protti, M.P., Lesina, M., and Algul, H. (2016). Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. Gastroenterology 151, 180-193 e112.

Minnen, A., Burmann, F., Wilhelm, L., Anchimiuk, A., Diebold-Durand, M.L., and Gruber, S. (2016). Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA. Cell Rep 14, 2003-2016.

Grassl, N., Kulak, N.A., Pichler, G., Geyer, P.E., Jung, J., Schubert, S., Sinitcyn, P., Cox, J., and Mann, M. (2016). Ultra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome. Genome Med 8, 44.

Keilhauer, E.C., Geyer, P.E., and Mann, M. (2016). HCD Fragmentation of Glycated Peptides. J Proteome Res 15, 2881-2890.

Scilabra, S.D., Yamamoto, K., Pigoni, M., Sakamoto, K., Muller, S.A., Papadopoulou, A., Lichtenthaler, S.F., Troeberg, L., Nagase, H., and Kadomatsu, K. (2016). Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue. Matrix Biol, 59, 69-79.

Reusswig, K.U., Zimmermann, F., Galanti, L., and Pfander, B. (2016). Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2. Cell Rep 17, 556-569.

Crevenna, A.H., Blank, B., Maiser, A., Emin, D., Prescher, J., Beck, G., Kienzle, C., Bartnik, K., Habermann, B., Pakdel, M., Leonhardt, H., Lamb, D.C., and von Blume, J. (2016). Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network. J Cell Biol 213, 305-314.

Schlichthaerle, T., Strauss, M.T., Schueder, F., Woehrstein, J.B., and Jungmann, R. (2016). DNA nanotechnology and fluorescence applications. Curr Opin Biotechnol 39, 41-47.

Feller, C., Forne, I., Imhof, A., and Becker, P.B. (2015). Global and specific responses of the histone acetylome to systematic perturbation. Mol Cell 57, 559-571.

Mullner, F.E., Wierenga, C.J., and Bonhoeffer, T. (2015). Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87, 576-589.

Deligiannaki, M., Casper, A.L., Jung, C., and Gaul, U. (2015). Pasiflora proteins are novel core components of the septate junction. Development 142, 3046-3057.

Hauser, T., Bhat, J.Y., Milicic, G., Wendler, P., Hartl, F.U., Bracher, A., and Hayer-Hartl, M. (2015). Structure and mechanism of the Rubisco-assembly chaperone Raf1. Nat Struct Mol Biol 22, 720-728.

Bracher, A., Hauser, T., Liu, C., Hartl, F.U., and Hayer-Hartl, M. (2015). Structural Analysis of the Rubisco-Assembly Chaperone RbcX-II from Chlamydomonas reinhardtii. PLoS One 10, e0135448.

Reuter, L.M., Meinel, D.M., and Strasser, K. (2015). The poly(A)-binding protein Nab2 functions in RNA polymerase III transcription. Genes Dev 29, 1565-1575.

Bachhuber, T., Katzmarski, N., McCarter, J.F., Loreth, D., Tahirovic, S., Kamp, F., Abou-Ajram, C., Nuscher, B., Serrano-Pozo, A., Muller, A., Prinz, M., Steiner, H., Hyman, B.T., Haass, C., and Meyer-Luehmann, M. (2015). Inhibition of amyloid-beta plaque formation by alpha-synuclein. Nat Med 21, 802-807.

Solchenberger, B., Russell, C., Kremmer, E., Haass, C., and Schmid, B. (2015). Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology. PLoS One 10, e0118956.

Bhaskar, V., Basquin, J., and Conti, E. (2015). Architecture of the ubiquitylation module of the yeast Ccr4-Not complex. Structure 23, 921-928.

Haldar, S., Gupta, A.J., Yan, X., Milicic, G., Hartl, F.U., and Hayer-Hartl, M. (2015). Chaperonin-Assisted Protein Folding: Relative Population of Asymmetric and Symmetric GroEL:GroES Complexes. J Mol Biol 427, 2244-2255.

Asano, S., Fukuda, Y., Beck, F., Aufderheide, A., Forster, F., Danev, R., and Baumeister, W. (2015). Proteasomes. A molecular census of 26S proteasomes in intact neurons. Science 347, 439-442.

Engel, B.D., Schaffer, M., Albert, S., Asano, S., Plitzko, J.M., and Baumeister, W. (2015). In situ structural analysis of Golgi intracisternal protein arrays. Proc Natl Acad Sci U S A 112, 11264-11269.

Butryn, A., Schuller, J.M., Stoehr, G., Runge-Wollmann, P., Forster, F., Auble, D.T., and Hopfner, K.P. (2015). Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1. Elife 4.

Butryn, A., Stoehr, G., Linke-Winnebeck, C., and Hopfner, K.P. (2015). Serendipitous crystallization and structure determination of cyanase (CynS) from Serratia proteamaculans. Acta Crystallogr F Struct Biol Commun 71, 471-476.

Nokwe, C.N., Hora, M., Zacharias, M., Yagi, H., John, C., Reif, B., Goto, Y., and Buchner, J. (2015). The antibody light chain linker is important for domain stability and amyloid formation. J Mol Biol 427, 3572-3586.

Jain, D., Baldi, S., Zabel, A., Straub, T., and Becker, P.B. (2015). Active promoters give rise to false positive 'Phantom Peaks' in ChIP-seq experiments. Nucleic Acids Res 43, 6959-6968.

Damijonaitis, A., Broichhagen, J., Urushima, T., Hull, K., Nagpal, J., Laprell, L., Schonberger, M., Woodmansee, D.H., Rafiq, A., Sumser, M.P., Kummer, W., Gottschalk, A., and Trauner, D. (2015). AzoCholine enables optical control of alpha 7 nicotinic acetylcholine receptors in neural networks. ACS Chem Neurosci 6, 701-707.

Beck, S., Michalski, A., Raether, O., Lubeck, M., Kaspar, S., Goedecke, N., Baessmann, C., Hornburg, D., Meier, F., Paron, I., Kulak, N.A., Cox, J., and Mann, M. (2015). The Impact II, a Very High-Resolution Quadrupole Time-of-Flight Instrument (QTOF) for Deep Shotgun Proteomics. Mol Cell Proteomics 14, 2014-2029.

Princz, L.N., Gritenaite, D., and Pfander, B. (2015). The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis. Cell Cycle 14, 488-494.

Willem, M., Tahirovic, S., Busche, M.A., Ovsepian, S.V., Chafai, M., Kootar, S., Hornburg, D., Evans, L.D., Moore, S., Daria, A., Hampel, H., Muller, V., Giudici, C., Nuscher, B., Wenninger-Weinzierl, A., Kremmer, E., Heneka, M.T., Thal, D.R., Giedraitis, V., Lannfelt, L., Muller, U., Livesey, F.J., Meissner, F., Herms, J., Konnerth, A., Marie, H., and Haass, C. (2015). eta-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 526, 443-447.

Kozlowski, M., and Ladurner, A.G. (2015). ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence. Mol Cell 59, 713-715.

Heger, K., Kober, M., Riess, D., Drees, C., de Vries, I., Bertossi, A., Roers, A., Sixt, M., and Schmidt-Supprian, M. (2015). A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors. Eur J Immunol 45, 1614-1620.

Santarelli, S., Namendorf, C., Anderzhanova, E., Gerlach, T., Bedenk, B., Kaltwasser, S., Wagner, K., Labermaier, C., Reichel, J., Drgonova, J., Czisch, M., Uhr, M., and Schmidt, M.V. (2015). The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior. J Psychiatr Res 68, 261-269.

Vardabasso, C., Gaspar-Maia, A., Hasson, D., Punzeler, S., Valle-Garcia, D., Straub, T., Keilhauer, E.C., Strub, T., Dong, J., Panda, T., Chung, C.Y., Yao, J.L., Singh, R., Segura, M.F., Fontanals-Cirera, B., Verma, A., Mann, M., Hernando, E., Hake, S.B., and Bernstein, E. (2015). Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma. Mol Cell 59, 75-88.

Zieske, K., and Schwille, P. (2015). Reconstituting geometry-modulated protein patterns in membrane compartments. Methods Cell Biol 128, 149-163.

Donnelly, N., and Storchova, Z. (2015). Causes and consequences of protein folding stress in aneuploid cells. Cell Cycle 14, 495-501.

Matheisl, S., Berninghausen, O., Becker, T., and Beckmann, R. (2015). Structure of a human translation termination complex. Nucleic Acids Res, [Epub ahead of print].

Laprell, L., Repak, E., Franckevicius, V., Hartrampf, F., Terhag, J., Hollmann, M., Sumser, M., Rebola, N., DiGregorio, D.A., and Trauner, D. (2015). Optical control of NMDA receptors with a diffusible photoswitch. Nat Commun 6, 8076.

Spadaro, M., Gerdes, L.A., Mayer, M.C., Ertl-Wagner, B., Laurent, S., Krumbholz, M., Breithaupt, C., Hogen, T., Straube, A., Giese, A., Hohlfeld, R., Lassmann, H., Meinl, E., and Kumpfel, T. (2015). Histopathology and clinical course of MOG-antibody-associated encephalomyelitis. Ann Clin Transl Neurol 2, 295-301.

Bauer, C., Gobel, K., Nagaraj, N., Colantuoni, C., Wang, M., Muller, U., Kremmer, E., Rottach, A., and Leonhardt, H. (2015). Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT). J Biol Chem 290, 4801-4812.

Durrbaum, M., and Storchova, Z. (2015). Consequences of Aneuploidy in Cancer: Transcriptome and Beyond. Recent Results Cancer Res 200, 195-224.

Wilhelm, L., Burmann, F., Minnen, A., Shin, H.C., Toseland, C.P., Oh, B.H., and Gruber, S. (2015). SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis. Elife 4.

Weidemann, T., Mucksch, J., and Schwille, P. (2014). Fluorescence fluctuation microscopy: a diversified arsenal of methods to investigate molecular dynamics inside cells. Curr Opin Struct Biol 28C, 69-76.

Cost, A.L., Ringer, P., Chrostek-Grashoff, A., and Grashoff, C. (2015). How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension Sensors. Cell Mol Bioeng 8, 96-105.

Schaupp, A., Sabet, O., Dudanova, I., Ponserre, M., Bastiaens, P., and Klein, R. (2014). The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol 204, 409-422.

Hornburg, D., Drepper, C., Butter, F., Meissner, F., Sendtner, M., and Mann, M. (2014). Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics. Mol Cell Proteomics 13, 3410-3420.

Lu, K., Psakhye, I., and Jentsch, S. (2014). Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family. Cell 158, 549-563.

Lu, K., Psakhye, I., and Jentsch, S. (2014). A new class of ubiquitin-Atg8 receptors involved in selective autophagy and polyQ protein clearance. Autophagy 10, 2381-2382.

Klein, P., Muller-Rischart, A.K., Motori, E., Schonbauer, C., Schnorrer, F., Winklhofer, K.F., and Klein, R. (2014). Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J 33, 779.

Gatto, G., Morales, D., Kania, A., and Klein, R. (2014). EphA4 receptor shedding regulates spinal motor axon guidance. Curr Biol 24, 2355-2365.

Koutrolos, M., Berer, K., Kawakami, N., Wekerle, H., and Krishnamoorthy, G. (2014). Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS. Acta Neuropathol Commun 2, 163.

Liebscher, S., Page, R.M., Kafer, K., Winkler, E., Quinn, K., Goldbach, E., Brigham, E.F., Quincy, D., Basi, G.S., Schenk, D.B., Steiner, H., Bonhoeffer, T., Haass, C., Meyer-Luehmann, M., and Hubener, M. (2014). Chronic gamma-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Mol Psychiatry 19, 937-946.

Renkawitz, J., Lademann, C.A., and Jentsch, S. (2014). Mechanisms and principles of homology search during recombination. Nat Rev Mol Cell Biol 15, 369-383.

Schuch, B., Feigenbutz, M., Makino, D.L., Falk, S., Basquin, C., Mitchell, P., and Conti, E. (2014). The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. EMBO J 33, 2829-2846.

Bhogaraju, S., and Lorentzen, E. (2014). Crystal structure of a Chlamydomonas reinhardtii flagellar RabGAP TBC-domain at 1.8 A resolution. Proteins 82, 2282-2287.

Bhogaraju, S., Weber, K., Engel, B.D., Lechtreck, K.F., and Lorentzen, E. (2014). Getting tubulin to the tip of the cilium: one IFT train, many different tubulin cargo-binding sites? Bioessays 36, 463-467.

Deeb, S.J., Cox, J., Schmidt-Supprian, M., and Mann, M. (2014). N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Mol Cell Proteomics 13, 240-251.

Galili, D.S., Dylla, K.V., Ludke, A., Friedrich, A.B., Yamagata, N., Wong, J.Y., Ho, C.H., Szyszka, P., and Tanimoto, H. (2014). Converging circuits mediate temperature and shock aversive olfactory conditioning in Drosophila. Curr Biol 24, 1712-1722.

Heger, K., Fierens, K., Vahl, J.C., Aszodi, A., Peschke, K., Schenten, D., Hammad, H., Beyaert, R., Saur, D., van Loo, G., Roers, A., Lambrecht, B.N., Kool, M., and Schmidt-Supprian, M. (2014a). A20-deficient mast cells exacerbate inflammatory responses in vivo. PLoS Biol 12, e1001762.

Heger, K., Seidler, B., Vahl, J.C., Schwartz, C., Kober, M., Klein, S., Voehringer, D., Saur, D., and Schmidt-Supprian, M. (2014b). CreER(T2) expression from within the c-Kit gene locus allows efficient inducible gene targeting in and ablation of mast cells. Eur J Immunol 44, 296-306.

Jack, A.P., and Hake, S.B. (2014). Getting down to the core of histone modifications. Chromosoma 123, 355-371.

Weitkunat, M., Kaya-Copur, A., Grill, S.W., and Schnorrer, F. (2014). Tension and force-resistant attachment are essential for myofibrillogenesis in Drosophila flight muscle. Curr Biol 24, 705-716.

Weitkunat, M., and Schnorrer, F. (2014). A guide to study Drosophila muscle biology. Methods 68, 2-14.

Wickles, S., Singharoy, A., Andreani, J., Seemayer, S., Bischoff, L., Berninghausen, O., Soeding, J., Schulten, K., van der Sluis, E.O., and Beckmann, R. (2014). A structural model of the active ribosome-bound membrane protein insertase YidC. Elife, e03035.

Seitl, I., Wickles, S., Beckmann, R., Kuhn, A., and Kiefer, D. (2014). The C-terminal regions of YidC from Rhodopirellula baltica and Oceanicaulis alexandrii bind to ribosomes and partially substitute for SRP receptor function in Escherichia coli. Mol Microbiol 91, 408-421.

Rojowska, A., Lammens, K., Seifert, F.U., Direnberger, C., Feldmann, H., and Hopfner, K.P. (2014). Structure of the Rad50 DNA double-strand break repair protein in complex with DNA. EMBO J 33, 2847-2859.

Raman, N., Nayak, A., and Muller, S. (2014). mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3. Mol Cell Biol 34, 4474-4484.

Bischoff, L., Wickles, S., Berninghausen, O., van der Sluis, E.O., and Beckmann, R. (2014). Visualization of a polytopic membrane protein during SecY-mediated membrane insertion. Nat Commun 5, 4103.

Georgescauld, F., Popova, K., Gupta, A.J., Bracher, A., Engen, J.R., Hayer-Hartl, M., and Hartl, F.U. (2014). GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding. Cell 157, 922-934.

Gupta, A.J., Haldar, S., Milicic, G., Hartl, F.U., and Hayer-Hartl, M. (2014). Active cage mechanism of chaperonin-assisted protein folding demonstrated at single-molecule level. J Mol Biol 426, 2739-2754.

Varga, J., De Oliveira, T., and Greten, F.R. (2014). The architect who never sleeps: tumor-induced plasticity. FEBS Lett 588, 2422-2427.

Nokwe, C.N., Zacharias, M., Yagi, H., Hora, M., Reif, B., Goto, Y., and Buchner, J. (2014). A residue-specific shift in stability and amyloidogenicity of antibody variable domains. J Biol Chem 289, 26829-26846.

Klingner, C., Cherian, A.V., Fels, J., Diesinger, P.M., Aufschnaiter, R., Maghelli, N., Keil, T., Beck, G., Tolic-Norrelykke, I.M., Bathe, M., and Wedlich-Soldner, R. (2014). Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells. J Cell Biol 207, 107-121.

Sun, Z., Lambacher, A., and Fassler, R. (2014). Nascent adhesions: from fluctuations to a hierarchical organization. Curr Biol 24, R801-803.

Schmalen, I., Reischl, S., Wallach, T., Klemz, R., Grudziecki, A., Prabu, J.R., Benda, C., Kramer, A., and Wolf, E. (2014). Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation. Cell 157, 1203-1215.

Schonberger, M., and Trauner, D. (2014). A photochromic agonist for mu-opioid receptors. Angew Chem Int Ed Engl 53, 3264-3267.

Schonberger, M., Althaus, M., Fronius, M., Clauss, W., and Trauner, D. (2014). Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat Chem 6, 712-719.

Thanisch, K., Schneider, K., Morbitzer, R., Solovei, I., Lahaye, T., Bultmann, S., and Leonhardt, H. (2014). Targeting and tracing of specific DNA sequences with dTALEs in living cells. Nucleic Acids Res 42, e38.

Broichhagen, J., Schonberger, M., Cork, S.C., Frank, J.A., Marchetti, P., Bugliani, M., Shapiro, A.M., Trapp, S., Rutter, G.A., Hodson, D.J., and Trauner, D. (2014). Optical control of insulin release using a photoswitchable sulfonylurea. Nat Commun 5, 5116.

Bischoff, L., Berninghausen, O., and Beckmann, R. (2014). Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep 9, 469-475.

May, S., Hornburg, D., Schludi, M.H., Arzberger, T., Rentzsch, K., Schwenk, B.M., Grasser, F.A., Mori, K., Kremmer, E., Banzhaf-Strathmann, J., Mann, M., Meissner, F., and Edbauer, D. (2014). C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration. Acta Neuropathol 128, 485-503.

Gritenaite, D., Princz, L.N., Szakal, B., Bantele, S.C., Wendeler, L., Schilbach, S., Habermann, B.H., Matos, J., Lisby, M., Branzei, D., and Pfander, B. (2014). A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication. Genes Dev 28, 1604-1619.

Santarelli, S., Lesuis, S.L., Wang, X.D., Wagner, K.V., Hartmann, J., Labermaier, C., Scharf, S.H., Muller, M.B., Holsboer, F., and Schmidt, M.V. (2014). Evidence supporting the match/mismatch hypothesis of psychiatric disorders. Eur Neuropsychopharmacol 24, 907-918.

Balsevich, G., Uribe, A., Wagner, K.V., Hartmann, J., Santarelli, S., Labermaier, C., and Schmidt, M.V. (2014a). Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51. J Endocrinol 222, 15-26.

Stangl, S., Varga, J., Freysoldt, B., Trajkovic-Arsic, M., Siveke, J.T., Greten, F.R., Ntziachristos, V., and Multhoff, G. (2014). Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe. Cancer Res 74, 6903-6912.

Zieske, K., and Schwille, P. (2014). Reconstitution of self-organizing protein gradients as spatial cues in cell-free systems. Elife 3.

Zieske, K., Schweizer, J., and Schwille, P. (2014). Surface topology assisted alignment of Min protein waves. FEBS Lett 588, 2545-2549.

Muller, U., Bauer, C., Siegl, M., Rottach, A., and Leonhardt, H. (2014). TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation. Nucleic Acids Res 42, 8592-8604.

Durrbaum, M., Kuznetsova, A.Y., Passerini, V., Stingele, S., Stoehr, G., and Storchova, Z. (2014). Unique features of the transcriptional response to model aneuploidy in human cells. BMC Genomics 15, 139.

Donnelly, N., Passerini, V., Durrbaum, M., Stingele, S., and Storchova, Z. (2014). HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells. EMBO J 33, 2374-2387.

Donnelly, N., and Storchova, Z. (2014). Dynamic karyotype, dynamic proteome: buffering the effects of aneuploidy. Biochim Biophys Acta 1843, 473-481.

Balsevich, G., Namendorf, C., Gerlach, T., Uhr, M., and Schmidt, M.V. (2014). The bio-distribution of the antidepressant clomipramine is modulated by chronic stress in mice: effects on behavior. Front Behav Neurosci 8, 445.

Vincenz, L., and Hartl, F.U. (2014). Sugarcoating ER Stress. Cell 156, 1125-1127.

Zhang, X., Koolhaas, W.H., and Schnorrer, F. (2014). A versatile two-step CRISPR- and RMCE-based strategy for efficient genome engineering in Drosophila. G3 (Bethesda) 4, 2409-2418.

Zhang, X., Ferreira, I.R., and Schnorrer, F. (2014). A simple TALEN-based protocol for efficient genome-editing in Drosophila. Methods 69, 32-37.

Weckmann, K., Labermaier, C., Asara, J.M., Muller, M.B., and Turck, C.W. (2014). Time-dependent metabolomic profiling of Ketamine drug action reveals hippocampal pathway alterations and biomarker candidates. Transl Psychiatry 4, e481.

Viturawong, T., Meissner, F., Butter, F., and Mann, M. (2013). A DNA-centric protein interaction map of ultraconserved elements reveals contribution of transcription factor binding hubs to conservation. Cell Rep 5, 531-545.

Krahmer, N., Hilger, M., Kory, N., Wilfling, F., Stoehr, G., Mann, M., Farese, R.V., Jr., and Walther, T.C. (2013). Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics 12, 1115-1126.

Li, J., and Buchner, J. (2013). Structure, function and regulation of the hsp90 machinery. Biomed J 36, 106-117.

Li, J., Zoldak, G., Kriehuber, T., Soroka, J., Schmid, F.X., Richter, K., and Buchner, J. (2013). Unique proline-rich domain regulates the chaperone function of AIPL1. Biochemistry 52, 2089-2096.

Li, J., Richter, K., Reinstein, J., and Buchner, J. (2013). Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle. Nat Struct Mol Biol 20, 326-331.

Seiradake, E., Schaupp, A., del Toro Ruiz, D., Kaufmann, R., Mitakidis, N., Harlos, K., Aricescu, A.R., Klein, R., and Jones, E.Y. (2013). Structurally encoded intraclass differences in EphA clusters drive distinct cell responses. Nat Struct Mol Biol 20, 958-964.

Girstmair, H., Saffert, P., Rode, S., Czech, A., Holland, G., Bannert, N., and Ignatova, Z. (2013). Depletion of cognate charged transfer RNA causes translational frameshifting within the expanded CAG stretch in huntingtin. Cell Rep 3, 148-159.

Jentsch, S., and Psakhye, I. (2013). Control of nuclear activities by substrate-selective and protein-group SUMOylation. Annu Rev Genet 47, 167-186.

Gatto, G., Dudanova, I., Suetterlin, P., Davies, A.M., Drescher, U., Bixby, J.L., and Klein, R. (2013). Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling. J Neurosci 33, 5399-5410.

Kinkelin, K., Wozniak, G.G., Rothbart, S.B., Lidschreiber, M., Strahl, B.D., and Cramer, P. (2013). Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue. Proc Natl Acad Sci U S A 110, 15277-15282.

Lidschreiber, M., Leike, K., and Cramer, P. (2013). Cap Completion and C-Terminal Repeat Domain Kinase Recruitment Underlie the Initiation-Elongation Transition of RNA Polymerase II. Mol Cell Biol 33, 3805-3816.

McCarter, J.F., Liebscher, S., Bachhuber, T., Abou-Ajram, C., Hubener, M., Hyman, B.T., Haass, C., and Meyer-Luehmann, M. (2013). Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathol 126, 179-188.

Webhofer, C., Zhang, Y., Brusis, J., Reckow, S., Landgraf, R., Maccarrone, G., Turck, C.W., and Filiou, M.D. (2013). (1)(5)N metabolic labeling: evidence for a stable isotope effect on plasma protein levels and peptide chromatographic retention times. J Proteomics 88, 27-33.

Webhofer, C., Gormanns, P., Reckow, S., Lebar, M., Maccarrone, G., Ludwig, T., Putz, B., Asara, J.M., Holsboer, F., Sillaber, I., Zieglgansberger, W., and Turck, C.W. (2013). Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates. J Psychiatr Res 47, 289-298.

Renkawitz, J., Lademann, C.A., and Jentsch, S. (2013). gammaH2AX spreading linked to homology search. Cell Cycle 12.

Renkawitz, J., Lademann, C.A., Kalocsay, M., and Jentsch, S. (2013). Monitoring homology search during DNA double-strand break repair in vivo. Mol Cell 50, 261-272.

Solovei, I., Wang, A.S., Thanisch, K., Schmidt, C.S., Krebs, S., Zwerger, M., Cohen, T.V., Devys, D., Foisner, R., Peichl, L., Herrmann, H., Blum, H., Engelkamp, D., Stewart, C.L., Leonhardt, H., and Joffe, B. (2013). LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell 152, 584-598.

Bhogaraju, S., Cajanek, L., Fort, C., Blisnick, T., Weber, K., Taschner, M., Mizuno, N., Lamla, S., Bastin, P., Nigg, E.A., and Lorentzen, E. (2013). Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science 341, 1009-1012.

Bhogaraju, S., Engel, B.D., and Lorentzen, E. (2013). Intraflagellar transport complex structure and cargo interactions. Cilia 2, 10.

Meinel, D.M., Burkert-Kautzsch, C., Kieser, A., O'Duibhir, E., Siebert, M., Mayer, A., Cramer, P., Soding, J., Holstege, F.C., and Strasser, K. (2013). Recruitment of TREX to the Transcription Machinery by Its Direct Binding to the Phospho-CTD of RNA Polymerase II. PLoS Genet 9, e1003914.

Hogl, S., van Bebber, F., Dislich, B., Kuhn, P.H., Haass, C., Schmid, B., and Lichtenthaler, S.F. (2013). Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics 13, 1519-1527.

Vahl, J.C., Heger, K., Knies, N., Hein, M.Y., Boon, L., Yagita, H., Polic, B., and Schmidt-Supprian, M. (2013). NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology. PLoS Biol 11, e1001589.

Jack, A.P., Bussemer, S., Hahn, M., Punzeler, S., Snyder, M., Wells, M., Csankovszki, G., Solovei, I., Schotta, G., and Hake, S.B. (2013). H3K56me3 Is a Novel, Conserved Heterochromatic Mark That Largely but Not Completely Overlaps with H3K9me3 in Both Regulation and Localization. PLoS One 8, e51765.

Orozco, D., and Edbauer, D. (2013).
FUS-mediated alternative splicing in the nervous system: consequences for ALS and FTLD.
J Mol Med (Berl) 91, 1343-1354.

Norousi, R., Wickles, S., Leidig, C., Becker, T., Schmid, V.J., Beckmann, R., and Tresch, A. (2013). Automatic post-picking using MAPPOS improves particle image detection from cryo-EM micrographs. J Struct Biol 182, 59-66.

Raman, N., Nayak, A., and Muller, S. (2013). The SUMO system: a master organizer of nuclear protein assemblies. Chromosoma 122, 475-485.

Bhaskar, V., Roudko, V., Basquin, J., Sharma, K., Urlaub, H., Seraphin, B., and Conti, E. (2013). Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex. Nat Struct Mol Biol 20, 1281-1288.

Fernandez-Busnadiego, R., Asano, S., Oprisoreanu, A.M., Sakata, E., Doengi, M., Kochovski, Z., Zurner, M., Stein, V., Schoch, S., Baumeister, W., and Lucic, V. (2013). Cryo-electron tomography reveals a critical role of RIM1alpha in synaptic vesicle tethering. J Cell Biol 201, 725-740.

Jasnin, M., Asano, S., Gouin, E., Hegerl, R., Plitzko, J.M., Villa, E., Cossart, P., and Baumeister, W. (2013). Three-dimensional architecture of actin filaments in Listeria monocytogenes comet tails. Proc Natl Acad Sci U S A 110, 20521-20526.

Muller-Rischart, A.K., Pilsl, A., Beaudette, P., Patra, M., Hadian, K., Funke, M., Peis, R., Deinlein, A., Schweimer, C., Kuhn, P.H., Lichtenthaler, S.F., Motori, E., Hrelia, S., Wurst, W., Trumbach, D., Langer, T., Krappmann, D., Dittmar, G., Tatzelt, J., and Winklhofer, K.F. (2013). The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO. Mol Cell 49, 908-921.

Dine, J., Ionescu, I.A., Stepan, J., Yen, Y.C., Holsboer, F., Landgraf, R., Eder, M., and Schmidt, U. (2013). Identification of a role for the ventral hippocampus in neuropeptide S-elicited anxiolysis. PLoS One 8, e60219.

Schweiger, R., Soll, J., Jung, K., Heermann, R., and Schwenkert, S. (2013). Quantification of interaction strengths between chaperones and tetratricopeptide repeat domain-containing membrane proteins. J Biol Chem 288, 30614-30625.

Schneider, K., Fuchs, C., Dobay, A., Rottach, A., Qin, W., Wolf, P., Alvarez-Castro, J.M., Nalaskowski, M.M., Kremmer, E., Schmid, V., Leonhardt, H., and Schermelleh, L. (2013). Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling. Nucleic Acids Res 41, 4860-4876.

Schiller, H.B., Hermann, M.R., Polleux, J., Vignaud, T., Zanivan, S., Friedel, C.C., Sun, Z., Raducanu, A., Gottschalk, K.E., Thery, M., Mann, M., and Fassler, R. (2013). beta1- and alphav-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol 15, 625-636.

Marcinowski, M., Rosam, M., Seitz, C., Elferich, J., Behnke, J., Bello, C., Feige, M.J., Becker, C.F., Antes, I., and Buchner, J. (2013). Conformational selection in substrate recognition by hsp70 chaperones. J Mol Biol 425, 466-474.

Jankevicius, G., Hassler, M., Golia, B., Rybin, V., Zacharias, M., Timinszky, G., and Ladurner, A.G. (2013). A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat Struct Mol Biol 20, 508-514.

Zieske, K., and Schwille, P. (2013). Reconstitution of Pole-to-Pole Oscillations of Min Proteins in Microengineered Polydimethylsiloxane Compartments. Angew Chem Int Ed Engl 52, 459-462.

Modic, M., Ule, J., and Sibley, C.R. (2013).
CLIPing the brain: studies of protein-RNA interactions important for neurodegenerative disorders.
Mol Cell Neurosci 56, 429-435.

Psakhye, I., and Jentsch, S. (2012) Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair. Cell 151, 807-820.

Sun, Z., and Fassler, R. (2012) A firm grip does not always pay off: a new Phact(r) 4 integrin signaling. Genes Dev 26, 1-5.

Maier, V.K., and Becker, P.B. (2012) A Defined In Vitro System to Study ATP-Dependent Remodeling of Short Chromatin Fibers. Methods Mol Biol 833, 255-270.

Butter, F., Davison, L., Viturawong, T., Scheibe, M., Vermeulen, M., Todd, J.A., and Mann, M. (2012) Proteome-Wide Analysis of Disease-Associated SNPs That Show Allele-Specific Transcription Factor Binding. PLoS Genet 8, e1002982.

Nagaraj, N., Kulak, N.A., Cox, J., Neuhauser, N., Mayr, K., Hoerning, O., Vorm, O., and Mann, M. (2012) System-wide perturbation analysis with nearly complete coverage of the yeast proteome by single-shot ultra HPLC runs on a bench top Orbitrap. Mol Cell Proteomics 11, M111 013722.

Deeb, S.J., D'Souza, R.C., Cox, J., Schmidt-Supprian, M., and Mann, M. (2012) Super-SILAC allows classification of diffuse large B-cell lymphoma subtypes by their protein expression profiles. Mol Cell Proteomics 11, 77-89.

Li, J., Soroka, J., and Buchner, J. (2012) The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones. Biochim Biophys Acta 1823, 624-635.

Azimifar, S.B., Bottcher, R.T., Zanivan, S., Grashoff, C., Kruger, M., Legate, K.R., Mann, M., and Fassler, R. (2012) Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor. J Cell Sci 125, 435-448.

Hilger, M., and Mann, M. (2012) Triple SILAC to determine stimulus specific interactions in the Wnt pathway. J Proteome Res 11, 982-994.

Mazur, P.K., and Siveke, J.T. (2012) Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology. Gut 61, 1488-1500.

Mazur, P.K., Riener, M.O., Jochum, W., Kristiansen, G., Weber, A., Schmid, R.M., and Siveke, J.T. (2012) Expression and clinicopathological significance of notch signaling and cell-fate genes in biliary tract cancer. Am J Gastroenterol 107, 126-135.

Gruner, B.M., Hahne, H., Mazur, P.K., Trajkovic-Arsic, M., Maier, S., Esposito, I., Kalideris, E., Michalski, C.W., Kleeff, J., Rauser, S., Schmid, R.M., Kuster, B., Walch, A., and Siveke, J.T. (2012) MALDI Imaging Mass Spectrometry for In Situ Proteomic Analysis of Preneoplastic Lesions in Pancreatic Cancer. PLoS One 7, e39424.

Ng, J.K., Malotka, J., Kawakami, N., Derfuss, T., Khademi, M., Olsson, T., Linington, C., Odaka, M., Tackenberg, B., Pruss, H., Schwab, J.M., Harms, L., Harms, H., Sommer, C., Rasband, M.N., Eshed-Eisenbach, Y., Peles, E., Hohlfeld, R., Yuki, N., Dornmair, K., and Meinl, E. (2012) Neurofascin as a target for autoantibodies in peripheral neuropathies. Neurology 79, 2241-2248.

Simon, C., Lickert, H., Gotz, M., and Dimou, L. (2012) Sox10-iCreER(T2) : A mouse line to inducibly trace the neural crest and oligodendrocyte lineage. Genesis 50, 506-515.

Russmann, F., Stemp, M.J., Monkemeyer, L., Etchells, S.A., Bracher, A., and Hartl, F.U. (2012) Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT. Proc Natl Acad Sci U S A 109, 21208-21215.

Feller, C., Prestel, M., Hartmann, H., Straub, T., Soding, J., and Becker, P.B. (2012) The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset. Nucleic Acids Res 40, 1509-1522.

Geiger, A., Russo, L., Gensch, T., Thestrup, T., Becker, S., Hopfner, K.P., Griesinger, C., Witte, G., and Griesbeck, O. (2012) Correlating Calcium Binding, Forster Resonance Energy Transfer, and Conformational Change in the Biosensor TN-XXL. Biophys J 102, 2401-2410.

Schmidt, C.S., Bultmann, S., Meilinger, D., Zacher, B., Tresch, A., Maier, K.C., Peter, C., Martin, D.E., Leonhardt, H., and Spada, F. (2012) Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. PLoS One 7, e52629.

Pichler, G., Jack, A., Wolf, P., and Hake, S.B. (2012a) Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteins. PLoS One 7, e36967.

Pichler, G., Leonhardt, H., and Rothbauer, U. (2012b) Fluorescent protein specific nanotraps to study protein-protein interactions and histone-tail Peptide binding. Methods Mol Biol 911, 475-483.

Filiou, M.D., Teplytska, L., Otte, D.M., Zimmer, A., and Turck, C.W. (2012) Myelination and oxidative stress alterations in the cerebellum of the G72/G30 transgenic schizophrenia mouse model. J Psychiatr Res 46, 1359-1365.

Filiou, M.D., Varadarajulu, J., Teplytska, L., Reckow, S., Maccarrone, G., and Turck, C.W. (2012) The (15) N isotope effect in Escherichia coli: A neutron can make the difference. Proteomics 12, 3121-3128.

Filiou, M.D., Martins-de-Souza, D., Guest, P.C., Bahn, S., and Turck, C.W. (2012) To label or not to label: applications of quantitative proteomics in neuroscience research. Proteomics 12, 736-747.

Filiou, M.D., and Turck, C.W. (2012) Psychiatric disorder biomarker discovery using quantitative proteomics. Methods Mol Biol 829, 531-539.

Filiou, M.D., Webhofer, C., Gormanns, P., Zhang, Y., Reckow, S., Bisle, B., Teplytska, L., Frank, E., Kessler, M.S., Maccarrone, G., Landgraf, R., and Turck, C.W. (2012d) The (15)N isotope effect as a means for correlating phenotypic alterations and affected pathways in a trait anxiety mouse model. Proteomics 12, 2421-2427.

Schnell, B., Raghu, S.V., Nern, A., and Borst, A. (2012) Columnar cells necessary for motion responses of wide-field visual interneurons in Drosophila. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198, 389-395.

Orozco, D., Tahirovic, S., Rentzsch, K., Schwenk, B.M., Haass, C., and Edbauer, D. (2012) Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. EMBO Rep 13, 759-764.

Schweiger, R., Muller, N.C., Schmitt, M.J., Soll, J., and Schwenkert, S. (2012) AtTPR7 is a chaperone docking protein of the Sec translocon in Arabidopsis. J Cell Sci 125, 5196-5207.

Franckenberg, S., Becker, T., and Beckmann, R. (2012) Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue. Curr Opin Struct Biol 22, 786-796.

Becker, T., Franckenberg, S., Wickles, S., Shoemaker, C.J., Anger, A.M., Armache, J.P., Sieber, H., Ungewickell, C., Berninghausen, O., Daberkow, I., Karcher, A., Thomm, M., Hopfner, K.P., Green, R., and Beckmann, R. (2012) Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Nature 482, 501-506.

Donhofer, A., Franckenberg, S., Wickles, S., Berninghausen, O., Beckmann, R., and Wilson, D.N. (2012) Structural basis for TetM-mediated tetracycline resistance. Proc Natl Acad Sci U S A 109, 16900-16905.

Scheibe, M., Butter, F., Hafner, M., Tuschl, T., and Mann, M. (2012) Quantitative mass spectrometry and PAR-CLIP to identify RNA-protein interactions. Nucleic Acids Res 40, 9897-9902.

Ardito, C.M., Gruner, B.M., Takeuchi, K.K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P.K., Delgiorno, K.E., Carpenter, E.S., Halbrook, C.J., Hall, J.C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G.Y., Storz, P., Murray, N.R., Threadgill, D.W., Sibilia, M., Washington, M.K., Wilson, C.L., Schmid, R.M., Raines, E.W., Crawford, H.C., and Siveke, J.T. (2012) EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis. Cancer Cell 22, 304-317.

Bonisch, C., Schneider, K., Punzeler, S., Wiedemann, S.M., Bielmeier, C., Bocola, M., Eberl, H.C., Kuegel, W., Neumann, J., Kremmer, E., Leonhardt, H., Mann, M., Michaelis, J., Schermelleh, L., and Hake, S.B. (2012) H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Nucleic Acids Res 40, 5951-5964.

Cardoso, M.C., Schneider, K., Martin, R.M., and Leonhardt, H. (2012) Structure, function and dynamics of nuclear subcompartments. Curr Opin Cell Biol 24, 79-85.

Taschner, M., Bhogaraju, S., and Lorentzen, E. (2012) Architecture and function of IFT complex proteins in ciliogenesis. Differentiation 83, S12-22.

Schenk, L., Meinel, D.M., Strasser, K., and Gerber, A.P. (2012) La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast. RNA 18, 449-461.

Chu, Y., Soberon, V., Glockner, L., Beyaert, R., Massoumi, R., van Loo, G., Krappmann, D., and Schmidt-Supprian, M. (2012) A20 and CYLD Do Not Share Significant Overlapping Functions during B Cell Development and Activation. J Immunol 189, 4437-4443.

Mayer, A., Heidemann, M., Lidschreiber, M., Schreieck, A., Sun, M., Hintermair, C., Kremmer, E., Eick, D., and Cramer, P. (2012a) CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II. Science 336, 1723-1725.

Niederberger, T., Etzold, S., Lidschreiber, M., Maier, K.C., Martin, D.E., Frohlich, H., Cramer, P., and Tresch, A. (2012) MC EMiNEM Maps the Interaction Landscape of the Mediator. PLoS Comput Biol 8, e1002568.

Mayer, A., Schreieck, A., Lidschreiber, M., Leike, K., Martin, D.E., and Cramer, P. (2012b) The spt5 C-terminal region recruits yeast 3' RNA cleavage factor I. Mol Cell Biol 32, 1321-1331.

Bultmann, S., Morbitzer, R., Schmidt, C.S., Thanisch, K., Spada, F., Elsaesser, J., Lahaye, T., and Leonhardt, H. (2012) Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Res 40, 5368-5377.

Kuhn, P.H., Koroniak, K., Hogl, S., Colombo, A., Zeitschel, U., Willem, M., Volbracht, C., Schepers, U., Imhof, A., Hoffmeister, A., Haass, C., Rossner, S., Brase, S., and Lichtenthaler, S.F. (2012) Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J 31, 3157-3168.

Chanarat, S., Burkert-Kautzsch, C., Meinel, D.M., and Strasser, K. (2012) Prp19C and TREX: Interacting to promote transcription elongation and mRNA export. Transcription 3, 8-12.

Aichler, M., Seiler, C., Tost, M., Siveke, J., Mazur, P.K., Da Silva-Buttkus, P., Bartsch, D.K., Langer, P., Chiblak, S., Durr, A., Hofler, H., Kloppel, G., Muller-Decker, K., Brielmeier, M., and Esposito, I. (2012) Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol 226, 723-734.

Akerboom, J., Chen, T.W., Wardill, T.J., Tian, L., Marvin, J.S., Mutlu, S., Calderon, N.C., Esposti, F., Borghuis, B.G., Sun, X.R., Gordus, A., Orger, M.B., Portugues, R., Engert, F., Macklin, J.J., Filosa, A., Aggarwal, A., Kerr, R.A., Takagi, R., Kracun, S., Shigetomi, E., Khakh, B.S., Baier, H., Lagnado, L., Wang, S.S., Bargmann, C.I., Kimmel, B.E., Jayaraman, V., Svoboda, K., Kim, D.S., Schreiter, E.R., and Looger, L.L. (2012) Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging. J Neurosci 32, 13819-13840.

Odoardi, F., Sie, C., Streyl, K., Ulaganathan, V.K., Schlager, C., Lodygin, D., Heckelsmiller, K., Nietfeld, W., Ellwart, J., Klinkert, W.E., Lottaz, C., Nosov, M., Brinkmann, V., Spang, R., Lehrach, H., Vingron, M., Wekerle, H., Flugel-Koch, C., and Flugel, A. (2012) T cells become licensed in the lung to enter the central nervous system. Nature 488, 675-679.

Gregory, A.P., Dendrou, C.A., Attfield, K.E., Haghikia, A., Xifara, D.K., Butter, F., Poschmann, G., Kaur, G., Lambert, L., Leach, O.A., Promel, S., Punwani, D., Felce, J.H., Davis, S.J., Gold, R., Nielsen, F.C., Siegel, R.M., Mann, M., Bell, J.I., McVean, G., and Fugger, L. (2012) TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 488, 508-511.

Widmaier, M., Rognoni, E., Radovanac, K., Azimifar, S.B., and Fassler, R. (2012) Integrin-linked kinase at a glance. J Cell Sci 125, 1839-1843.

Ross, K., Sedello, A.K., Todd, G.P., Paszkowski-Rogacz, M., Bird, A.W., Ding, L., Grinenko, T., Behrens, K., Hubner, N., Mann, M., Waskow, C., Stocking, C., and Buchholz, F. (2012) Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells. Blood 119, 4152-4161.

Leitner, A., Joachimiak, L.A., Bracher, A., Monkemeyer, L., Walzthoeni, T., Chen, B., Pechmann, S., Holmes, S., Cong, Y., Ma, B., Ludtke, S., Chiu, W., Hartl, F.U., Aebersold, R., and Frydman, J. (2012) The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT. Structure 20, 814-825.

Chu, Y., Soberon, V., Glockner, L., Beyaert, R., Massoumi, R., van Loo, G., Krappmann, D., and Schmidt-Supprian, M. (2012) A20 and CYLD Do Not Share Significant Overlapping Functions during B Cell Development and Activation. J Immunol 189, 4437-4443.

Strasser, D., Neumann, K., Bergmann, H., Marakalala, M.J., Guler, R., Rojowska, A., Hopfner, K.P., Brombacher, F., Urlaub, H., Baier, G., Brown, G.D., Leitges, M., and Ruland, J. (2012) Syk kinase-coupled C-type lectin receptors engage protein kinase C-sigma to elicit Card9 adaptor-mediated innate immunity. Immunity 36, 32-42.

Chen, X., Leischner, U., Varga, Z., Jia, H., Deca, D., Rochefort, N.L., and Konnerth, A. (2012) LOTOS-based two-photon calcium imaging of dendritic spines in vivo. Nat Protoc 7, 1818-1829.

Ali, A.A., Timinszky, G., Arribas-Bosacoma, R., Kozlowski, M., Hassa, P.O., Hassler, M., Ladurner, A.G., Pearl, L.H., and Oliver, A.W. (2012) The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Nat Struct Mol Biol 19, 685-692.

 

Ringel, R., Sologub, M., Morozov, Y.I., Litonin, D., Cramer, P., and Temiakov, D. (2011) Structure of human mitochondrial RNA polymerase. Nature 478, 269-273.

Schonbauer, C., Distler, J., Jahrling, N., Radolf, M., Dodt, H.U., Frasch, M., and Schnorrer, F. (2011) Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects. Nature 479, 406-409.

Li, J., Richter, K., and Buchner, J. (2011). Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle. Nat Struct Mol Biol 18, 61-66.

Stotz, M., Mueller-Cajar, O., Ciniawsky, S., Wendler, P., Hartl, F.U., Bracher, A., and Hayer-Hartl, M. (2011) Structure of green-type Rubisco activase from tobacco. Nat Struct Mol Biol 18, 1366-1370.

Fava, L.L., Kaulich, M., Nigg, E.A., and Santamaria, A. (2011) Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint. EMBO J 30, 3322-3336.

Bhogaraju, S., Taschner, M., Morawetz, M., Basquin, C., and Lorentzen, E. (2011). Crystal structure of the intraflagellar transport complex 25/27. EMBO J. 30, 1907-1918.

Blattner, C., Jennebach, S., Herzog, F., Mayer, A., Cheung, A.C., Witte, G., Lorenzen, K., Hopfner, K.P., Heck, A.J., Aebersold, R., and Cramer, P. (2011) Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth. Genes Dev 25, 2093-2105.

Pichler, G., Wolf, P., Schmidt, C.S., Meilinger, D., Schneider, K., Frauer, C., Fellinger, K., Rottach, A., and Leonhardt, H. (2011). Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways. J Cell Biochem 112, 2585-2593.

Frauer, C., Rottach, A., Meilinger, D., Bultmann, S., Fellinger, K., Hasenoder, S., Wang, M., Qin, W., Soding, J., Spada, F., and Leonhardt, H. (2011). Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1. PLoS One 6, e16627.

Frauer, C., Hoffmann, T., Bultmann, S., Casa, V., Cardoso, M.C., Antes, I., and Leonhardt, H. (2011) Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain. PLoS One 6, e21306.

Frauer, C., and Leonhardt, H. (2011). Twists and turns of DNA methylation. Proc Natl Acad Sci U S A, 108, 8919-8920.

Nagaraj, N., and Mann, M. (2011). Quantitative analysis of the intra- and inter-individual variability of the normal urinary proteome. J Proteome Res 10, 637-645.

Nagaraj, N., Wisniewski, J.R., Geiger, T., Cox, J., Kircher, M., Kelso, J., Paabo, S., and Mann, M. (2011) Deep proteome and transcriptome mapping of a human cancer cell line. Mol Syst Biol 7, 548.

Filiou, M.D., Turck, C.W., and Martins-de-Souza, D. (2011). Quantitative proteomics for investigating psychiatric disorders. Proteomics Clin Appl 5, 38-49.

Filiou, M.D., and Turck, C.W. (2011) General overview: Biomarkers in neuroscience research. Int Rev Neurobiol 101, 1-17.

Filiou, M.D., Zhang, Y., Teplytska, L., Reckow, S., Gormanns, P., Maccarrone, G., Frank, E., Kessler, M.S., Hambsch, B., Nussbaumer, M., Bunck, M., Ludwig, T., Yassouridis, A., Holsboer, F., Landgraf, R., and Turck, C.W. (2011) Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways. Biol Psychiatry 70, 1074-1082.

Borwankar, T., Rothlein, C., Zhang, G., Techen, A., Dosche, C., and Ignatova, Z. (2011). Natural Osmolytes Remodel the Aggregation Pathway of Mutant Huntingtin Exon 1. Biochemistry 50, 2048-2060.

Hubner, N.C., and Mann, M. (2011). Extracting gene function from protein-protein interactions using Quantitative BAC InteraCtomics (QUBIC). Methods 53, 453-459.

Simon, C., Gotz, M., and Dimou, L. (2011). Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury. Glia 59, 869-881.

Galili, D.S., Ludke, A., Galizia, C.G., Szyszka, P., and Tanimoto, H. (2011). Olfactory trace conditioning in Drosophila. J Neurosci 31, 7240-7248.

Jung, S.N., Borst, A., and Haag, J. (2011) Flight activity alters velocity tuning of fly motion-sensitive neurons. J Neurosci 31, 9231-9237.

Hogl, S., Kuhn, P.H., Colombo, A., and Lichtenthaler, S.F. (2011) Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and gamma-Secretase. PLoS One 6, e21337.

Kovacs-Bogdan, E., Benz, J.P., Soll, J., and Bolter, B. (2011) Tic20 forms a channel independent of Tic110 in chloroplasts. BMC Plant Biol 11, 133.

Acevedo-Rocha, C.G., and Budisa, N. (2011) On the road towards chemically modified organisms endowed with a genetic firewall. Angew Chem Int Ed Engl 50, 6960-6962.

Khouri, L., Lesica, N.A., and Grothe, B. (2011) Impaired auditory temporal selectivity in the inferior colliculus of aged mongolian gerbils. J Neurosci 31, 9958-9970.

Kreile, A.K., Bonhoeffer, T., and Hubener, M. (2011) Altered visual experience induces instructive changes of orientation preference in mouse visual cortex. J Neurosci 31, 13911-13920.

Lamberti, G., Gugel, I.L., Meurer, J., Soll, J., and Schwenkert, S. (2011a) The Cytosolic Kinases STY8, STY17, and STY46 Are Involved in Chloroplast Differentiation in Arabidopsis. Plant Physiol 157, 70-85.

Lamberti, G., Drurey, C., Soll, J., and Schwenkert, S. (2011b) The phosphorylation state of chloroplast transit peptides regulates preprotein import. Plant Signal Behav 6.

Webhofer, C., Gormanns, P., Tolstikov, V., Zieglgansberger, W., Sillaber, I., Holsboer, F., and Turck, C.W. (2011) Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation. Translational Psychiatry 1.

Mueller-Cajar, O., Stotz, M., Wendler, P., Hartl, F.U., Bracher, A., and Hayer-Hartl, M. (2011) Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Nature 479, 194-199.

Wagener, N., Ackermann, M., Funes, S., and Neupert, W. (2011) A Pathway of Protein Translocation in Mitochondria Mediated by the AAA-ATPase Bcs1. Mol Cell 44, 191-202.

Vanhecke, D., Asano, S., Kochovski, Z., Fernandez-Busnadiego, R., Schrod, N., Baumeister, W., and Lucic, V. (2011). Cryo-electron tomography: methodology, developments and biological applications. J Microsc 242, 221-227.

Capell, A., Liebscher, S., Fellerer, K., Brouwers, N., Willem, M., Lammich, S., Gijselinck, I., Bittner, T., Carlson, A.M., Sasse, F., Kunze, B., Steinmetz, H., Jansen, R., Dormann, D., Sleegers, K., Cruts, M., Herms, J., Van Broeckhoven, C., and Haass, C. (2011). Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase. J Neurosci 31, 1885-1894.

Taschner, M., Bhogaraju, S., Vetter, M., Morawetz, M., and Lorentzen, E. (2011). Biochemical mapping of interactions within the intraflagellar transport (IFT) B core complex: IFT52 binds directly to four other IFT-B subunits. J Biol Chem. 286, 26344-26352.

Fellerer, C., Schweiger, R., Schongruber, K., Soll, J., and Schwenkert, S. (2011). Cytosolic HSP90 Cochaperones HOP and FKBP Interact with Freshly Synthesized Chloroplast Preproteins of Arabidopsis. Mol Plant 4, 1133-1145.

Zhang, Y., Filiou, M.D., Reckow, S., Gormanns, P., Maccarrone, G., Kessler, M.S., Frank, E., Hambsch, B., Holsboer, F., Landgraf, R., and Turck, C.W. (2011) Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways. Mol Cell Proteomics 10, M111 008110.

Monetti, M., Nagaraj, N., Sharma, K., and Mann, M. (2011) Large-scale phosphosite quantification in tissues by a spike-in SILAC method. Nat Methods 8, 655-658.

Berer, K., Mues, M., Koutrolos, M., Rasbi, Z.A., Boziki, M., Johner, C., Wekerle, H., and Krishnamoorthy, G. (2011) Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479, 538-541.

Popov-Celeketic, D., Waegemann, K., Mapa, K., Neupert, W., and Mokranjac, D. (2011). Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex. EMBO Rep. 12, 542-548.

Nickelsen, J., Rengstl, B., Stengel, A., Schottkowski, M., Soll, J., and Ankele, E. (2011). Biogenesis of the cyanobacterial thylakoid membrane system--an update. FEMS Microbiol Lett 315, 1-5.

Krastev, D.B., Slabicki, M., Paszkowski-Rogacz, M., Hubner, N.C., Junqueira, M., Shevchenko, A., Mann, M., Neugebauer, K.M., and Buchholz, F. (2011). A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Nat Cell Biol. 13, 809-818.

Schnutgen, F., Ehrmann, F., Poser, I., Hubner, N.C., Hansen, J., Floss, T., Devries, I., Wurst, W., Hyman, A., Mann, M., and von Melchner, H. (2011). Resources for proteomics in mouse embryonic stem cells. Nat Methods 8, 103-104.

Nitzsche, A., Paszkowski-Rogacz, M., Matarese, F., Janssen-Megens, E.M., Hubner, N.C., Schulz, H., de Vries, I., Ding, L., Huebner, N., Mann, M., Stunnenberg, H.G., and Buchholz, F. (2011). RAD21 Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity. PLoS One 6, e19470.

Hellal, F., Hurtado, A., Ruschel, J., Flynn, K.C., Laskowski, C.J., Umlauf, M., Kapitein, L.C., Strikis, D., Lemmon, V., Bixby, J., Hoogenraad, C.C., and Bradke, F. (2011). Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science 331, 928-931.

Szwagierczak, A., Brachmann, A., Schmidt, C.S., Bultmann, S., Leonhardt, H., and Spada, F. (2011). Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5-hydroxymethylcytosine. Nucleic Acids Res. 39, 5149-5156.

Zhang, Y., Reckow, S., Webhofer, C., Boehme, M., Gormanns, P., Egge-Jacobsen, W.M., and Turck, C.W. (2011). Proteome Scale Turnover Analysis in Live Animals Using Stable Isotope Metabolic Labeling. Anal Chem. 83, 1665-1672.

Chu, Y., Vahl, J.C., Kumar, D., Heger, K., Bertossi, A., Wojtowicz, E., Soberon, V., Schenten, D., Mack, B., Reutelshofer, M., Beyaert, R., Amann, K., van Loo, G., and Schmidt-Supprian, M. (2011). B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. Blood 117, 2227-2236.

Heid, I., Lubeseder-Martellato, C., Sipos, B., Mazur, P.K., Lesina, M., Schmid, R.M., and Siveke, J.T. (2011) Early requirement of rac1 in a mouse model of pancreatic cancer. Gastroenterology 141, 719-730 e717.

Michalski, A., Damoc, E., Hauschild, J.P., Lange, O., Wieghaus, A., Makarov, A., Nagaraj, N., Cox, J., Mann, M., and Horning, S. (2011) Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer. Mol Cell Proteomics 10, M111 011015.

Krahmer, N., Guo, Y., Wilfling, F., Hilger, M., Lingrell, S., Heger, K., Newman, H.W., Schmidt-Supprian, M., Vance, D.E., Mann, M., Farese, R.V., Jr., and Walther, T.C. (2011) Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase. Cell Metab 14, 504-515.

Otte, D.M., Sommersberg, B., Kudin, A., Guerrero, C., Albayram, O., Filiou, M.D., Frisch, P., Yilmaz, O., Drews, E., Turck, C.W., Bilkei-Gorzo, A., Kunz, W.S., Beck, H., and Zimmer, A. (2011) N-acetyl Cysteine Treatment Rescues Cognitive Deficits Induced by Mitochondrial Dysfunction in G72/G30 Transgenic Mice. Neuropsychopharmacology 36, 2233-2243.

Gross, D.P., Burgard, C.A., Reddehase, S., Leitch, J.M., Culotta, V.C., and Hell, K. (2011) Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system. Mol Biol Cell 22, 3758-3767.

Zhai, J., Zhou, W., Li, J., Hayworth, C.R., Zhang, L., Misawa, H., Klein, R., Scherer, S.S., Balice-Gordon, R.J., and Kalb, R.G. (2011) The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease. Hum Mol Genet 20, 4116-4131.

Eichner, H., Joesch, M., Schnell, B., Reiff, D.F., and Borst, A. (2011) Internal structure of the fly elementary motion detector. Neuron 70, 1155-1164.

Elefsinioti, A., Sarac, O.S., Hegele, A., Plake, C., Hubner, N.C., Poser, I., Sarov, M., Hyman, A., Mann, M., Schroeder, M., Stelzl, U., and Beyer, A. (2011) Large-scale De Novo Prediction of Physical Protein-Protein Association. Mol Cell Proteomics 10, M111 010629.

Nitzsche, A., Paszkowski-Rogacz, M., Matarese, F., Janssen-Megens, E.M., Hubner, N.C., Schulz, H., de Vries, I., Ding, L., Huebner, N., Mann, M., Stunnenberg, H.G., and Buchholz, F. (2011) RAD21 Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity. PLoS One 6, e19470.

Fernandez-Busnadiego, R., Schrod, N., Kochovski, Z., Asano, S., Vanhecke, D., Baumeister, W., and Lucic, V. (2011) Insights into the molecular organization of the neuron by cryo-electron tomography. J Electron Microsc (Tokyo) 60 Suppl 1, S137-148.

Qin, W., Leonhardt, H., and Pichler, G. (2011) Regulation of DNA methyltransferase 1 by interactions and modifications. Nucleus 2.

Wollmann, P., Cui, S., Viswanathan, R., Berninghausen, O., Wells, M.N., Moldt, M., Witte, G., Butryn, A., Wendler, P., Beckmann, R., Auble, D.T., and Hopfner, K.P. (2011) Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP. Nature 475, 403-407.

Touma, C., Gassen, N.C., Herrmann, L., Cheung-Flynn, J., Bull, D.R., Ionescu, I.A., Heinzmann, J.M., Knapman, A., Siebertz, A., Depping, A.M., Hartmann, J., Hausch, F., Schmidt, M.V., Holsboer, F., Ising, M., Cox, M.B., Schmidt, U., and Rein, T. (2011) FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol Psychiatry 70, 928-936.

Fehrentz, T., Schonberger, M., and Trauner, D. (2011) Optochemical genetics. Angew Chem Int Ed Engl 50, 12156-12182.

Sejourne, J., Placais, P.Y., Aso, Y., Siwanowicz, I., Trannoy, S., Thoma, V., Tedjakumala, S.R., Rubin, G.M., Tchenio, P., Ito, K., Isabel, G., Tanimoto, H., and Preat, T. (2011) Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila. Nat Neurosci 14, 903-910.

Hassler, M., Jankevicius, G., and Ladurner, A.G. (2011) PARG: A Macrodomain in Disguise. Structure 19, 1351-1353.

Bertossi, A., Aichinger, M., Sansonetti, P., Lech, M., Neff, F., Pal, M., Wunderlich, F.T., Anders, H.J., Klein, L., and Schmidt-Supprian, M. (2011) Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med 208, 1749-175.

Lakshmipathy, S.K., Gupta, R., Pinkert, S., Etchells, S.A., and Hartl, F.U. (2010). Versatility of trigger factor interactions with ribosome-nascent chain complexes. J Biol Chem 285, 27911-27923.

Gupta, R., Lakshmipathy, S.K., Chang, H.C., Etchells, S.A., and Hartl, F.U. (2010). Trigger factor lacking the PPIase domain can enhance the folding of eukaryotic multi-domain proteins in Escherichia coli. FEBS Lett 584, 3620-3624.

Mazur, P.K., Einwachter, H., Lee, M., Sipos, B., Nakhai, H., Rad, R., Zimber-Strobl, U., Strobl, L.J., Radtke, F., Kloppel, G., Schmid, R.M., and Siveke, J.T. (2010a). Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A 107, 13438-13443.

Mazur, P.K., Gruner, B.M., Nakhai, H., Sipos, B., Zimber-Strobl, U., Strobl, L.J., Radtke, F., Schmid, R.M., and Siveke, J.T. (2010b). Identification of epidermal pdx1 expression discloses different roles of notch1 and notch2 in murine kras-induced skin carcinogenesis in vivo. PLoS One 5, e13578.

Blamowska, M., Sichting, M., Mapa, K., Mokranjac, D., Neupert, W., and Hell, K. (2010). ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1. J Biol Chem 285, 4423-4431.

Mapa, K., Sikor, M., Kudryavtsev, V., Waegemann, K., Kalinin, S., Seidel, C.A., Neupert, W., Lamb, D.C., and Mokranjac, D. (2010). The conformational dynamics of the mitochondrial hsp70 chaperone. Mol Cell 38, 89-100.

Sun, N., Pan, C., Nickell, S., Mann, M., Baumeister, W., and Nagy, I. (2010). Quantitative proteome and transcriptome analysis of the archaeon Thermoplasma acidophilum cultured under aerobic and anaerobic conditions. J Proteome Res 9, 4839-4850.

Alte, F., Stengel, A., Benz, J.P., Petersen, E., Soll, J., Groll, M., and Bolter, B. (2010). Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner. Proc Natl Acad Sci U S A 107, 19260-19265.

Stengel, A., Benz, J.P., Soll, J., and Bolter, B. (2010). Redox-regulation of protein import into chloroplasts and mitochondria: similarities and differences. Plant Signal Behav 5, 105-109.

Guderian, G., Westendorf, J., Uldschmid, A., and Nigg, E.A. (2010). Plk4 trans-autophosphorylation regulates centriole number by controlling {beta}TrCP-mediated degradation. J Cell Sci.

Grothe, B., Pecka, M., and McAlpine, D. (2010). Mechanisms of sound localization in mammals. Physiol Rev 90, 983-1012.

Pecka, M., Siveke, I., Grothe, B., and Lesica, N.A. (2010). Enhancement of ITD coding within the initial stages of the auditory pathway. J Neurophysiol 103, 38-46.

Vermeulen, M., Eberl, H.C., Matarese, F., Marks, H., Denissov, S., Butter, F., Lee, K.K., Olsen, J.V., Hyman, A.A., Stunnenberg, H.G., and Mann, M. (2010). Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers. Cell 142, 967-980.

Butter, F., Kappei, D., Buchholz, F., Vermeulen, M., and Mann, M. (2010). A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth. EMBO Rep 11, 305-311.

Wisniewski, J.R., Nagaraj, N., Zougman, A., Gnad, F., and Mann, M. (2010). Brain Phosphoproteome Obtained by a FASP-Based Method Reveals Plasma Membrane Protein Topology. J Proteome Res 9, 3280-3289.

Nagaraj, N., D'Souza, R.C., Cox, J., Olsen, J.V., and Mann, M. (2010). Feasibility of large-scale phosphoproteomics with higher energy collisional dissociation fragmentation. J Proteome Res 9, 6786-6794.

Filiou, M.D., Bisle, B., Reckow, S., Teplytska, L., Maccarrone, G., and Turck, C.W. (2010). Profiling of mouse synaptosome proteome and phosphoproteome by IEF. Electrophoresis 31, 1294-1301.

Joesch, M., Schnell, B., Raghu, S.V., Reiff, D.F., and Borst, A. (2010). ON and OFF pathways in Drosophila motion vision. Nature 468, 300-304.

Schnell, B., Joesch, M., Forstner, F., Raghu, S.V., Otsuna, H., Ito, K., Borst, A., and Reiff, D.F. (2010). Processing of horizontal optic flow in three visual interneurons of the Drosophila brain. J Neurophysiol 103, 1646-1657.

Chakraborty, K., Chatila, M., Sinha, J., Shi, Q., Poschner, B.C., Sikor, M., Jiang, G., Lamb, D.C., Hartl, F.U., and Hayer-Hartl, M. (2010). Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding. Cell 142, 112-122.

Armache, J.P., Jarasch, A., Anger, A.M., Villa, E., Becker, T., Bhushan, S., Jossinet, F., Habeck, M., Dindar, G., Franckenberg, S., Marquez, V., Mielke, T., Thomm, M., Berninghausen, O., Beatrix, B., Soding, J., Westhof, E., Wilson, D.N., and Beckmann, R. (2010a). Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Proc Natl Acad Sci U S A 107, 19748-19753.

Armache, J.P., Jarasch, A., Anger, A.M., Villa, E., Becker, T., Bhushan, S., Jossinet, F., Habeck, M., Dindar, G., Franckenberg, S., Marquez, V., Mielke, T., Thomm, M., Berninghausen, O., Beatrix, B., Soding, J., Westhof, E., Wilson, D.N., and Beckmann, R. (2010b). Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome. Proc Natl Acad Sci U S A 107, 19754-19759.

Hubner, N.C., Bird, A.W., Cox, J., Splettstoesser, B., Bandilla, P., Poser, I., Hyman, A., and Mann, M. (2010). Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions. J Cell Biol 189, 739-754.

Kirchhofer, A., Helma, J., Schmidthals, K., Frauer, C., Cui, S., Karcher, A., Pellis, M., Muyldermans, S., Casas-Delucchi, C.S., Cardoso, M.C., Leonhardt, H., Hopfner, K.P., and Rothbauer, U. (2010). Modulation of protein properties in living cells using nanobodies. Nat Struct Mol Biol 17, 133-138.

Rottach, A., Frauer, C., Pichler, G., Bonapace, I.M., Spada, F., and Leonhardt, H. (2010). The multi-domain protein Np95 connects DNA methylation and histone modification. Nucleic Acids Res 38, 1796-1804.

Beckervordersandforth, R., Tripathi, P., Ninkovic, J., Bayam, E., Lepier, A., Stempfhuber, B., Kirchhoff, F., Hirrlinger, J., Haslinger, A., Lie, D.C., Beckers, J., Yoder, B., Irmler, M., and Gotz, M. (2010). In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell 7, 744-758.

Kovacs-Bogdan, E., Soll, J., and Bolter, B. (2010). Protein import into chloroplasts: the Tic complex and its regulation. Biochim Biophys Acta 1803, 740-747.

Friedrich, M.W., Aramuni, G., Mank, M., Mackinnon, J.A., and Griesbeck, O. (2010). Imaging CREB activation in living cells. J Biol Chem 285, 23285-23295.

Aron, L., Klein, P., Pham, T.T., Kramer, E.R., Wurst, W., and Klein, R. (2010). Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS Biol 8, e1000349.

Rother, S., Burkert, C., Brunger, K.M., Mayer, A., Kieser, A., and Strasser, K. (2010). Nucleocytoplasmic shuttling of the La motif-containing protein Sro9 might link its nuclear and cytoplasmic functions. RNA 16, 1393-1401.

Dudanova, I., Gatto, G., and Klein, R. (2010). GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons. Curr Biol 20, 2150-2156.

Prestel, M., Feller, C., and Becker, P.B. (2010). Dosage compensation and the global re-balancing of aneuploid genomes. Genome Biol 11, 216.

Mayer, A., Lidschreiber, M., Siebert, M., Leike, K., Soding, J., and Cramer, P. (2010). Uniform transitions of the general RNA polymerase II transcription complex. Nat Struct Mol Biol 17, 1272-1278.

Wierenga, C.J., Mullner, F.E., Rinke, I., Keck, T., Stein, V., and Bonhoeffer, T. (2010). Molecular and Electrophysiological Characterization of GFP-Expressing CA1 Interneurons in GAD65-GFP Mice. PLoS One 5, e15915.

Vannini, A., Ringel, R., Kusser, A.G., Berninghausen, O., Kassavetis, G.A., and Cramer, P. (2010). Molecular Basis of RNA Polymerase III Transcription Repression by Maf1. Cell 143, 59-70.

Szwagierczak, A., Bultmann, S., Schmidt, C.S., Spada, F., and Leonhardt, H. (2010). Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res 38, e181.

Renkawitz, J., and Sixt, M. (2010). Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Rep 11, 744-750.

Schnorrer, F., Schonbauer, C., Langer, C.C., Dietzl, G., Novatchkova, M., Schernhuber, K., Fellner, M., Azaryan, A., Radolf, M., Stark, A., Keleman, K., and Dickson, B.J. (2010). Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Nature 464, 287-291.

Langer, C.C., Ejsmont, R.K., Schonbauer, C., Schnorrer, F., and Tomancak, P. (2010). In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura. PLoS One 5, e8928.

Jahrling, N., Becker, K., Schonbauer, C., Schnorrer, F., and Dodt, H.U. (2010). Three-dimensional reconstruction and segmentation of intact Drosophila by ultramicroscopy. Front Syst Neurosci 4, .

Filosa, A., Paixao, S., Honsek, S.D., Carmona, M.A., Becker, L., Feddersen, B., Gaitanos, L., Rudhard, Y., Schoepfer, R., Klopstock, T., Kullander, K., Rose, C.R., Pasquale, E.B., and Klein, R. (2009). Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci. 12, 1285-1292.

Renkawitz, J., Schumann, K., Weber, M., Lammermann, T., Pflicke, H., Piel, M., Polleux, J., Spatz, J.P., and Sixt, M. (2009). Adaptive force transmission in amoeboid cell migration. Nat Cell Biol 11, 1438-1443.

Lammermann, T., Renkawitz, J., Wu, X., Hirsch, K., Brakebusch, C., and Sixt, M. (2009). Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood 113, 5703-5710.

Meilinger, D., Fellinger, K., Bultmann, S., Rothbauer, U., Bonapace, I.M., Klinkert, W.E., Spada, F., and Leonhardt, H. (2009). Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep 10, 1259-1264.

Fellinger, K., Rothbauer, U., Felle, M., Langst, G., and Leonhardt, H. (2009). Dimerization of DNA Methyltransferase 1 Is Mediated by Its Regulatory Domain. Journal of Cellular Biochemistry 106, 521-528.

Blamowska, M., Sichting, M., Mapa, K., Mokranjac, D., Neupert, W., and Hell, K. (2009). ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1. J Biol Chem. 285, 4423-4431.

Gevorkyan-Airapetov, L., Zohary, K., Popov-Celeketic, D., Mapa, K., Hell, K., Neupert, W., Azem, A., and Mokranjac, D. (2009). Interaction of Tim23 with Tim50 Is Essential for Protein Translocation by the Mitochondrial TIM23 Complex. J. Biol. Chem. 284, 4865-4872.

Mokranjac, D., Sichting, M., Popov-Celeketic, D., Mapa, K., Gevorkyan-Airapetov, L., Zohary, K., Hell, K., Azem, A., and Neupert, W. (2009). Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria. Mol Biol Cell 20, 1400-1407.

Stengel, A., Benz, J.P., Buchanan, B.B., Soll, J., and Bolter, B. (2009). Preprotein Import into Chloroplasts via the Toc and Tic Complexes Is Regulated by Redox Signals in Pisum sativum. Mol Plant 2, 1181-1197.

Benz, J.P., Stengel, A., Lintala, M., Lee, Y.H., Weber, A., Philippar, K., Gugel, I.L., Kaieda, S., Ikegami, T., Mulo, P., Soll, J., and Bolter, B. (2009). Arabidopsis Tic62 and ferredoxin-NADP(H) oxidoreductase form light-regulated complexes that are integrated into the chloroplast redox poise. Plant Cell 21, 3965-3983.

Frank, E., Kessler, M.S., Filiou, M.D., Zhang, Y., Maccarrone, G., Reckow, S., Bunck, M., Heumann, H., Turck, C.W., Landgraf, R., and Hambsch, B. (2009). Stable isotope metabolic labeling with a novel N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies. PLoS One 4, e7821.

Otte, D.M., Bilkei-Gorzo, A., Filiou, M.D., Turck, C.W., Yilmaz, O., Holst, M.I., Schilling, K., Abou-Jamra, R., Schumacher, J., Benzel, I., Kunz, W.S., Beck, H., and Zimmer, A. (2009). Behavioral changes in G72/G30 transgenic mice. Eur Neuropsychopharmacol 19, 339-348.

Zhang, Y., Webhofer, C., Reckow, S., Filiou, M.D., Maccarrone, G., and Turck, C.W. (2009). A MS data search method for improved 15N-labeled protein identification. Proteomics 9, 4265-4270.

Haegler, K., Mueller, N.S., Maccarrone, G., Hunyadi-Gulyas, E., Webhofer, C., Filiou, M.D., Zhang, Y.Y., and Turck, C.W. (2009). QuantiSpec - Quantitative mass spectrometry data analysis of N-15-metabolically labeled proteins. Journal of Proteomics 71, 601-608.

Wisniewski, J.R., Zougman, A., Nagaraj, N., and Mann, M. (2009). Universal sample preparation method for proteome analysis. Nature Methods 6, 359-U360.

Cox, J., Matic, I., Hilger, M., Nagaraj, N., Selbach, M., Olsen, J.V., and Mann, M. (2009). A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics. Nature Protocols 4, 698-705.

Hilger, M., Bonaldi, T., Gnad, F., and Mann, M. (2009). Systems-wide analysis of a phosphatase knock-down by quantitative proteomics and phosphoproteomics. Mol Cell Proteomics 8, 1908-1920.

Muller, S., Cremer, M., Neusser, M., Grasser, F., and Cremer, T. (2009). A Technical Note on Quantum Dots for Multi-Color Fluorescence in situ Hybridization. Cytogenetic and Genome Research 124, 351-359.

Pippig, D.A., Hellmuth, J.C., Cui, S., Kirchhofer, A., Lammens, K., Lammens, A., Schmidt, A., Rothenfusser, S., and Hopfner, K.P. (2009). The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA. Nucleic Acids Research 37, 2014-2025.

Pan, C.P., Olsen, J.V., Daub, H., and Mann, M. (2009). Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics. 8, 2796-2808.

Pan, C.P., Kumar, C., Bohl, S., Klingmueller, U., and Mann, M. (2009b). Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions. Mol Cell Prot 8, 443-450.

Frauer, C., and Leonhardt, H. (2009). A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding. Nucleic Acids Research 37.

Kalocsay, M., Hiller, N.J., and Jentsch, S. (2009). Chromosome-wide Rad51 Spreading and SUMO-H2A.Z-Dependent Chromosome Fixation in Response to a Persistent DNA Double-Strand Break. Mol. Cell 33, 335-343.

Mittler, G., Butter, F., and Mann, M. (2009). A SILAC-based DNA protein interaction screen that identifies candidate binding proteins to functional DNA elements. Genome Research 19, 284-293.

Butter, F., Scheibe, M., Morl, M., and Mann, M. (2009). Unbiased RNA-protein interaction screen by quantitative proteomics. Proc Natl Acad Sci USA 106, 10626-10631.

Balsera, M., Goetze, T.A., Kovacs-Bogdan, E., Schurmann, P., Wagner, R., Buchanan, B.B., Soll, J., and Bolter, B. (2009). Characterization of Tic110, a Channel-forming Protein at the Inner Envelope Membrane of Chloroplasts, Unveils a Response to Ca2+ and a Stromal Regulatory Disulfide Bridge. J Biol Chem 284, 2603-2616.

Reddehase, S., Grumbt, B., Neupert, W., and Hell, K. (2009). The Disulfide Relay System of Mitochondria Is Required for the Biogenesis of Mitochondrial Ccs1 and Sod1. J Mol Biol 385, 331-338.

von Burstin, J., Eser, S., Paul, M.C., Seidler, B., Brandl, M., Messer, M., von Werder, A., Schmidt, A., Mages, J., Pagel, P., Schnieke, A., Schmid, R.M., Schneider, G., and Saur, D. (2009). E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex. Gastroenterology 137, 361-371.

Chan, Y.W., Fava, L.L., Uldschmid, A., Schmitz, M.H.A., Gerlich, D.W., Nigg, E.A., and Santamaria, A. (2009). Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. Journal of Cell Biology 185, 859-874.

Frohlich, F., Moreira, K., Aguilar, P.S., Hubner, N.C., Mann, M., Walter, P., and Walther, T.C. (2009). A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol 185, 1227-1242.

Schmidt, T.I., Kleylein-Sohn, J., Westendorf, J., Le Clech, M., Lavoie, S.B., Stierhof, Y.D., and Nigg, E.A. (2009). Control of Centriole Length by CPAP and CP110. Current Biology 19, 1005-1011.

Cremer, M., Grasser, F., Lanctot, C., Muller, S., Neusser, M., Zinner, R., Solovei, I., and Cremer, T. (2008). Multicolor 3D Fluorescence In Situ Hybridization for Imaging Interphase Chromosomes. Methods Mol Biol 463, 205-239.

Graumann, J., Hubner, N.C., Kim, J.B., Ko, K., Moser, M., Kumar, C., Cox, J., Scholer, H., and Mann, M. (2008). Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and proteome quantitation of mouse embryonic stem cells to a depth of 5,111 proteins. Mol Cell Prot 7, 672-683.

Maier, V.K., Chioda, M., and Becker, P.B. (2008). ATP-dependent chromatosome remodeling. Biol Chem 389, 345-352.

Geisler, F., Nagl, F., Mazur, P.K., Lee, M., Zimber-Strobl, U., Strobl, L.J., Radtke, F., Schmid, R.M., and Siveke, J.T. (2008). Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. Hepatology 48, 607-616.

Nakhai, H., Siveke, J.T., Klein, B., Mendoza-Torres, L., Mazur, P.K., Algul, H., Radtke, F., Strobl, L., Zimber-Strobl, U., and Schmid, R.M. (2008). Conditional ablation of Notch signaling in pancreatic development. Development 135, 2757-2765.

Vermeulen, M., Hubner, N.C., and Mann, M. (2008). High confidence determination of specific protein-protein interactions using quantitative mass spectrometry. Curr Opinion Biotechnol 19, 331-337.

Cox, J., Hubner, N.C., and Mann, M. (2008). How Much Peptide Sequence Information Is Contained in Ion Trap Tandem Mass Spectra? J Am Soc Mass Spectrometry 19, 1813-1820.

Hubner, N.C., Ren, S., and Mann, M. (2008). Peptide separation with immobilized pI strips is an attractive alternative to in-gel protein digestion for proteome analysis. Proteomics 8, 4862-4872.

Bonisch, C., Nieratschker, S.M., Orfanos, N.K., and Hake, S.B. (2008). Chromatin proteomics and epigenetic regulatory circuits. Expert Review of Proteomics 5, 105-119.

Fellinger, K., Leonhardt, H., and Spada, F. (2008). A mutagenesis strategy combining systematic alanine scanning with larger mutations to study protein interactions. Analytical Biochemistry 373, 176-178.

Siveke, J.T., Lubeseder-Martellato, C., Lee, M., Mazur, P.K., Nakhai, H., Radtke, F., and Schmid, R.M. (2008). Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology 134, 544-555.

Hendel, T., Mank, M., Schnell, B., Griesbeck, O., Borst, A., and Reiff, D.F. (2008). Fluorescence changes of genetic calcium indicators and OGB-1 correlated with neural activity and calcium in vivo and in vitro. J Neurosci 28, 7399-7411.

Magnusson, A.K., Park, T.J., Pecka, M., Grothe, B., and Koch, U. (2008). Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem. Neuron 59, 125-137.

Pecka, M., Brand, A., Behrend, O., and Grothe, B. (2008). Interaural time difference processing in the mammalian medial superior olive: The role of glycinergic inhibition. J Neurosci 28, 6914-6925.

Seidler, B., Schmidt, A., Mayr, U., Nakhai, H., Schmid, R.M., Schneider, G., and Saur, D. (2008). A Cre-IoXP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. Proc Natl Acad Sci U S A 105, 10137-10142.

Grasser, F., Neusser, M., Fiegler, H., Thormeyer, T., Cremer, M., Carter, N.P., Cremer, T., and Muller, S. (2008). Replication-timing-correlated spatial chromatin arrangements in cancer and in primate interphase nuclei. J Cell Sci 121, 1876-1886.

Maier, V.K., Chioda, M., Rhodes, D., and Becker, P.B. (2008). ACF catalyses chromatosome movements in chromatin fibres. EMBO J 27, 817-826.

Stengel, A., Benz, P., Balsera, M., Soll, J., and Bolter, B. (2008). TIC62 redox-regulated translocon composition and dynamics. J Biol Chem 283, 6656-6667.

Geiger, S.R., Kuhn, C.D., Leidig, C., Renkawitz, J., and Cramer, P. (2008). Crystallization of RNA polymerase I subcomplex A14/A43 by iterative prediction, probing and removal of flexible regions. Acta Crystallographica Section F-Structural Biology and Crystallization Communications 64, 413-418.

Popov-Celeketic, D., Mapa, K., Neupert, W., and Mokranjac, D. (2008). Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. EMBO J 27, 1469-1480.

Nagaraj, N., Lu, A.P., Mann, M., and Wisniewski, J.R. (2008). Detergent-Based but Gel-Free Method Allows Identification of Several Hundred Membrane Proteins in Single LC-MS Runs. J Prot Res 7, 5028-5032.

Pan, C., Gnad, F., Olsen, J.V., and Mann, M. (2008). Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-4546.

de Godoy, L.M.F., Olsen, J.V., Cox, J., Nielsen, M.L., Hubner, N.C., Frohlich, F., Walther, T.C., and Mann, M. (2008). Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast. Nature 455, 1251-U1260.

Dimou, L., Simon, C., Kirchhoff, F., Takebayashi, H., and Gotz, M. (2008). Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex. J Neurosci 28, 10434-10442.

Matic, I., Macek, B., Hilger, M., Walther, T.C., and Mann, M. (2008). Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution. J Prot Res 7, 4050-4057.

Mertins, P., Eberl, H.C., Renkawitz, J., Olsen, J.V., Tremblay, M.L., Mann, M., Ullrich, A., and Daub, H. (2008). Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Prot 7, 1763-1777.

de Godoy, L., Cox, J., Olsen, J., Bonaldi, T., Kumar, C., Hubner, N., Macek, B., and Mann, M. (2007). Expression proteomics at last; the determination of Proteome wide protein abundance changes by SILAC and high resolution mass Spectrometry. Mol Cell Prot 6, 18-18.

Hermann, J., Pecka, M., von Gersdorff, H., Grothe, B., and Klug, A. (2007). Synaptic transmission at the calyx of Held under in vivo-like activity levels. J Neurophys 98, 807-820.

Kleylein-Sohn, J., Westendorf, J., Le Clech, M., Habedanck, R., Stierhof, Y.D., and Nigg, E.A. (2007). Plk4-induced centriole biogenesis in human cells. Dev Cell 13, 190-202.

Schroder, B., Wrocklage, C., Pan, C., Jager, R., Kosters, B., Schafer, H., Elsasser, H.P., Mann, M., and Hasilik, A. (2007). Integral and associated lysosomal membrane proteins. Traffic 8, 1676-1686.

Pecka, M., Zahn, T.P., Saunier-Rebori, B., Siveke, I., Felmy, F., Wiegrebe, L., Klug, A., Pollak, G.D., and Grothe, B. (2007). Inhibiting the inhibition: A neuronal network for sound localization in reverberant environments. J Neurosci 27, 1782-1790.

Balsera, M., Stengel, A., Soll, J., and Bolter, B. (2007). Tic62: a protein family from metabolism to protein translocation. Bmc Evolutionary Biology 7.

Wegmeyer, H., Egea, J., Rabe, N., Gezelius, H., Filosa, A., Enjin, A., Varoqueaux, F., Deininger, K., Schnuetgen, F., Brose, N., Klein, R., Kullander, K., and Betz, A. (2007). EphA4-Dependent axon guidance is mediated by the RacGAP alpha 2-chirnaerin. Neuron 55, 756-767.

Siveke, I., Pecka, M., Seidl, A.H., Baudoux, S., and Grothe, B. (2006). Binaural response properties of low-frequency neurons in the gerbil dorsal nucleus of the lateral lemniscus. J Neurophys 96, 1425-1440.

Straub, T., Gilfillan, G.D., Maier, V.K., and Becker, P.B. (2005). The Drosophila MSL complex activates the transcription of target genes. Genes & Development 19, 2284-2288.